NAH - Pituitary Dwarfism/German Shepherd Dog

Race liée: 
Growth retardation
Description: 
Underdevelopment of the pituitary gland leading to pituitary hormone deficiency causing growth retardation
Symptomes: 
Marked growth retardation, small size, retention of puppy coat, lack of adult coat, bilateral symetrical loss of hair coat mostly located at the trunk, the neck and at the top of the legs Less frequent signs : hyperpigmentation of the skin, scales, bacterial infections
Age d'aparition: 
Significated clinical signs 2-3 months after birth
Fréquence: 
11% carriers in French population
Gène impliqué: 
LHX3
Mutation testée: 
7bp del intron 5 affects splice site
Transmission: 
Autosomal Recessive
Brevet: 
-
Remarques: 
-