LPN1 - Juvenile-Onset Inherited Polyneuropathy/Saint Bernard Dog

Neuromuscular Degeneration

Description: 
Severe and progressive neuromuscular degeneration
Symptomes: 
Slowly worsening exercise intolerance, gait abnormalities, muscle atrophy of the pelvic limbs, noisy breathing, bark change, difficulty breathing
Age d'aparition: 
Before 4 years old
Fréquence: 
2% carriers
Gène impliqué: 
ARHGEF10
Mutation testée: 
c.1955_1958+6delCACGGTGAGC
Transmission: 
Autosomal Recessive
Brevet: 
-
Remarques: 
An another DNA test (LPN2) is available to detect an other form of polyneuropathy in this breed.