HSF4-A - Hereditary Cataract/Berger Australien

Lens opacity and blindness

Description: 
Lens opacity which affect both eyes (not obligatory at the same time)
Symptomes: 
Observation of two different cataracts in this breed: - mild, early-onset, seldom leading to loss of vision - severe, may affect vision
Age d'aparition: 
_
Fréquence: 
21% heterozygotes and 2% mutated homozygotes
Gène impliqué: 
HSF4
Mutation testée: 
g.85286582delC
Transmission: 
Autosomal Codominant
Brevet: 
_
Remarques: 
Heterozygotes may have the mild form, homozygous mutated dogs mainly develop the severe form. 17% of dogs with bilateral cataracts are not associate with the mutation HSF4-A.