DM-SOD1B - Degenerative Myelopathy/Bernese Mountain Dog

Progressive paralysis

Description: 
Degenerative disease of the spinal cord causing progressive paralysis
Symptomes: 
Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age d'aparition: 
Between 8 and 14 years old
Fréquence: 
American population: 7% carriers French population: 12% carriers
Gène impliqué: 
SOD1
Mutation testée: 
c.52A>T
Transmission: 
Autosomal Recessive
Brevet: 
-
Remarques: 
An another DNA test (DM-SOD1A) is available to detect an other form of degenerative myelopathy in this breed. Note : dogs heterozygous for both SOD1A and SOD1B can also develop degenerative myelopathy associated to this double heterozygosity.