ANTAGENE produces an unique genetic fingerprint of a dog or a cat
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Poisoning after drug admission
Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs
Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death
Age of onset : From birth
Frequency : 5%
Gene involved : MDR1
Tested mutation : c.227_230delATAG
Transmission : Autosomal Codominant
Patent : VHL Licence
Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.
Progressive paralysis
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
Growth retardation
Description: Underdevelopment of the pituitary gland leading to pituitary hormone deficiency causing growth retardation
Symptoms : Marked growth retardation, small size, retention of puppy coat, lack of adult coat, bilateral symetrical loss of hair coat mostly located at the trunk, the neck and at the top of the legs Less frequent signs : hyperpigmentation of the skin, scales, bacterial infections
Age of onset : Significated clinical signs 2-3 months after birth
Frequency : -
Gene involved : LHX3
Tested mutation : 7bp del intron 5 affects splice site
Transmission : Autosomal Recessive
Patent : -
Notes :
Long coat / Short coat
Description: DNA test can identifying dogs carrying the genotype "Long Coat"
Symptoms : _
Age of onset : _
Frequency : -
Gene involved : FGF5
Tested mutation : c.284G>T
Transmission : Autosomal Recessive
Patent : _
Notes : _