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White Swiss Shepherd
White Swiss Shepherd
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
MDR1 - Multidrug Sensitivity
Poisoning after drug admission
White Swiss Shepherd
MDR1 - Multidrug Sensitivity
Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs
Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death
Age of onset : From birth
Frequency : 5%
Gene involved : MDR1
Tested mutation : c.227_230delATAG
Transmission : Autosomal Codominant
Patent : VHL Licence
Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.
DM - Degenerative Myelopathy
Progressive paralysis
White Swiss Shepherd
DM - Degenerative Myelopathy
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
NAH - Pituitary Dwarfism
Growth retardation
White Swiss Shepherd
NAH - Pituitary Dwarfism
Description: Underdevelopment of the pituitary gland leading to pituitary hormone deficiency causing growth retardation
Symptoms : Marked growth retardation, small size, retention of puppy coat, lack of adult coat, bilateral symetrical loss of hair coat mostly located at the trunk, the neck and at the top of the legs Less frequent signs : hyperpigmentation of the skin, scales, bacterial infections
Age of onset : Significated clinical signs 2-3 months after birth
Frequency : -
Gene involved : LHX3
Tested mutation : 7bp del intron 5 affects splice site
Transmission : Autosomal Recessive
Patent : -
Notes :
PL - Hair Length
Long coat / Short coat
White Swiss Shepherd
PL - Hair Length
Description: DNA test can identifying dogs carrying the genotype "Long Coat"
Symptoms : _
Age of onset : _
Frequency : -
Gene involved : FGF5
Tested mutation : c.284G>T
Transmission : Autosomal Recessive
Patent : _
Notes : _