ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Bone proliferation
Description: Non-cancerous proliferating disease altering form and function of the bones of the skull and jaw bone
Symptoms : During the bony proliferation phase, difficulties in chewing, swelling and thickening of the jaw, pain, recurrent fever
Age of onset : Between 4 and 7 months old
Frequency : Not available
Gene involved : SLC37A2
Tested mutation : c.1332C>T
Transmission : Autosomal Dominant with incomplete penetrance
Patent : -
Notes : Because of incomplete penetrance and varying expressivity, many of the dogs carrying the CMO mutation will live without showing clinical signs
Mild bleeding disorder
Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation
Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases
Age of onset : From birth
Frequency : Not available
Gene involved : VWF
Tested mutation : c.7142C>T
Transmission : Autosomal Recessive
Patent : _
Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs
Krabbe disease
Description: Lysosomal strorage disease causing severe neuronal degeneration
Symptoms : Weakness of the limbs, tremors, uncoordinated movement, blindness, behavioural disorder
Age of onset : Between 1 and 5 months old
Frequency : Not available
Gene involved : GALC
Tested mutation : c.473A>C
Transmission : Autosomal Recessive
Patent : -
Notes :
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
ANTAGENE produces an unique genetic fingerprint of a dog or a cat