ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Painful and blinding disease
Description: Reduced drainage of fluid from the eye causing a build-up of pressure, enlargement of the eyes and lens luxation
Symptoms : Ocular pain, blinking, tearing, redness, blindness
Age of onset : Between 4 and 6 years old
Frequency : 50% carriers
Gene involved : ADAMTS17
Tested mutation : c.3070-3075delCGTGGT
Transmission : Autosomal Recessive
Patent : -
Notes : -
Presence of brown coat
Description: DNA test can identifying dogs carrying the genotype "Brown" (B Locus)
Symptoms : _
Age of onset : _
Frequency : _
Gene involved : TYRP1
Tested mutation : S41C, Q331X and 345delP
Transmission : Autosomal Recessive
Patent : _
Notes : _
Lighter black or brown coat colour
Description: DNA test can identifying dogs carrying the genotype "Dilute" (D Locus)
Symptoms : Dilution or lightening effect of the black or brown colours
Age of onset : From birth
Frequency : _
Gene involved : MLPH
Tested mutation : c.-22G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Kidney failure
Speciality Nephrology
Description : Amyloid deposits in kidney
Symptoms : Excessive water consumption, weight loss, fatigue. Progressive and ultimately fatal renal failure
Age of onset : The age of cases is 2–12 years with a median of 6 years
Examination : Definitive diagnosis can be made only by histological analysis on kidney biopsy or post-mortem sample of kidney.
Progress : Thanks to the important participation of breeders, veterinarians and dog owners, we have been able to collect 99 samples of Shar-Pei older than 18 months and histologically characterized for renal amyloidosis. Among them, 40 were diagnosed with amyloidosi
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL). In case of death, whatever the reason : • Sample and put promptly a half kidney (sagittal section) in formalin for histological analysis, and a piece of tissue in alcohol (e.g. tongue) for DNA extraction. ANTAGENE co
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Teams of Dr Kerstin Lindblad-Toh (Broad Institute, Massachussetts, USA and Uppsala University, Sweden), Dr J. Abadie (National Veterinary School of Nantes, France) and Dr L. Tintle (USA)
Contact : mageane@antagene.com
Comment : Your involvement in research is essential to our progress.