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Shar Pei
Shar Pei
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
POAG-PLL - Primary Open Angle Glaucoma and Primary Lens Luxation
Painful and blinding disease
Shar Pei
POAG-PLL - Primary Open Angle Glaucoma and Primary Lens Luxation
Description: Reduced drainage of fluid from the eye causing a build-up of pressure, enlargement of the eyes and lens luxation
Symptoms : Ocular pain, blinking, tearing, redness, blindness
Age of onset : Between 4 and 6 years old
Frequency : 50% carriers
Gene involved : ADAMTS17
Tested mutation : c.3070-3075delCGTGGT
Transmission : Autosomal Recessive
Patent : -
Notes : -
COUL-1 - B Locus
Presence of brown coat
Shar Pei
COUL-1 - B Locus
Description: DNA test can identifying dogs carrying the genotype "Brown" (B Locus)
Symptoms : _
Age of onset : _
Frequency : _
Gene involved : TYRP1
Tested mutation : S41C, Q331X and 345delP
Transmission : Autosomal Recessive
Patent : _
Notes : _
DIL - Dilution (D Locus)
Lighter black or brown coat colour
Shar Pei
DIL - Dilution (D Locus)
Description: DNA test can identifying dogs carrying the genotype "Dilute" (D Locus)
Symptoms : Dilution or lightening effect of the black or brown colours
Age of onset : From birth
Frequency : _
Gene involved : MLPH
Tested mutation : c.-22G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Renal Amyloidosis
Kidney failure
Shar Pei
Renal Amyloidosis
Speciality Nephrology
Description : Amyloid deposits in kidney
Symptoms : Excessive water consumption, weight loss, fatigue. Progressive and ultimately fatal renal failure
Age of onset : The age of cases is 2–12 years with a median of 6 years
Examination : Definitive diagnosis can be made only by histological analysis on kidney biopsy or post-mortem sample of kidney.
Progress : Thanks to the important participation of breeders, veterinarians and dog owners, we have been able to collect 99 samples of Shar-Pei older than 18 months and histologically characterized for renal amyloidosis. Among them, 40 were diagnosed with amyloidosi
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL). In case of death, whatever the reason : • Sample and put promptly a half kidney (sagittal section) in formalin for histological analysis, and a piece of tissue in alcohol (e.g. tongue) for DNA extraction. ANTAGENE co
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Teams of Dr Kerstin Lindblad-Toh (Broad Institute, Massachussetts, USA and Uppsala University, Sweden), Dr J. Abadie (National Veterinary School of Nantes, France) and Dr L. Tintle (USA)
Contact : mageane@antagene.com
Comment : Your involvement in research is essential to our progress.