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Rough Collie
Rough Collie
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
MDR1 - Multidrug Sensitivity
Poisoning after drug admission
Rough Collie
MDR1 - Multidrug Sensitivity
Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs
Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death
Age of onset : From birth
Frequency : 85%
Gene involved : MDR1
Tested mutation : c.227_230delATAG
Transmission : Autosomal Codominant
Patent : VHL Licence
Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.
DM - Degenerative Myelopathy
Progressive paralysis
Rough Collie
DM - Degenerative Myelopathy
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
VWD2 - von Willebrand's Disease Type II
Moderate to severe bleeding disorder
Rough Collie
VWD2 - von Willebrand's Disease Type II
Description: Low level and abnormal function of von Willebrand factor, a protein involved in blood coagulation
Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal, excessive gingival haemorrhage during eruption of adult teeth, nose bleeding, skin bruising, prolonged bleeding after surgery or trauma
Age of onset : From birth
Frequency : Not available
Gene involved : VWF
Tested mutation : A>G in a2 domain
Transmission : Autosomal Recessive
Patent : -
Notes :
MERLE - Merle Coat Colour
M locus
Rough Collie
MERLE - Merle Coat Colour
Description: DNA test can identify dogs carrying the genotype "Merle" (M Locus) and highlight double merles and cryptic merles
Symptoms : Patches of diluted pigment intermingled with normal melanin, blue eyes, often associated with a wide range of auditory and ophthalmologic abnormalities. Double merles are predominantly white
Age of onset : From birth
Frequency : Not available
Gene involved : SILV
Tested mutation : SINE insertion
Transmission : Autosomal Dominant
Patent : -
Notes :
CEA - Collie Eye Anomaly (Choroidal Hypoplasia - Optigen payment 130$)
Loss of vision
Rough Collie
CEA - Collie Eye Anomaly (Choroidal Hypoplasia - Optigen payment 130$)
Description: Abnormal development of the choroid (a layer of tissue under the retina of the eye)
Symptoms : Variability of clinical signs according to the breed and individuals: - grade 1 and 2: mild form, without disablement and evolution - grade 3 and 4: severe form with retinal detachment and intraocular haemorrhage, might cause blindness
Age of onset : From the age of 8 weeks
Frequency : Not available
Gene involved : NHEJ1
Tested mutation : c.588+462_588+8260del7799bp
Transmission : Autosomal Recessive
Patent : _
Notes : Mild and severe forms being due to a single mutation in the same gene, dogs with a mild form may produce offspring presenting a severe form.
DMS - Dermatomyositis (Optigen payment 100$)
Skin lesions
Rough Collie
DMS - Dermatomyositis (Optigen payment 100$)
Description: Autoimmune disease of the skin and muscle
Symptoms : Hair loss and crusts on face, ear tips, legs and feet, and the tip of the tail. In affected Collies, muscle wasting manifests as atrophy of the head musculature, difficulty eating, drinking, and swallowing and an atypical, high-stepping gait. Muscle involvement is uncommon in Shelties.
Age of onset : Variable (as early as 12 weeks of age or in mature dogs)
Frequency : Not available
Gene involved : PAN2, MAP3K7CL and DLA-DRB1
Tested mutation : PAN2:g.627760G>A, MAP3K7CL:c.383_392ACTCCACAAA>GACT and DLA-DRB1*002:01
Transmission : Multifactorial
Patent : -
Notes : In some affected puppies, lesions may diminish with age and may or may not return at an older age. DMS is determined by a combination of genetic and environmental factors (vaccination, viral infection, stress, UV exposure, owner surrender, mistreatment)
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten