ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Poisoning after drug admission
Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs
Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death
Age of onset : From birth
Frequency : 85%
Gene involved : MDR1
Tested mutation : c.227_230delATAG
Transmission : Autosomal Codominant
Patent : VHL Licence
Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.
Progressive paralysis
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
Moderate to severe bleeding disorder
Description: Low level and abnormal function of von Willebrand factor, a protein involved in blood coagulation
Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal, excessive gingival haemorrhage during eruption of adult teeth, nose bleeding, skin bruising, prolonged bleeding after surgery or trauma
Age of onset : From birth
Frequency : Not available
Gene involved : VWF
Tested mutation : A>G in a2 domain
Transmission : Autosomal Recessive
Patent : -
Notes :
M locus
Description: DNA test can identify dogs carrying the genotype "Merle" (M Locus) and highlight double merles and cryptic merles
Symptoms : Patches of diluted pigment intermingled with normal melanin, blue eyes, often associated with a wide range of auditory and ophthalmologic abnormalities. Double merles are predominantly white
Age of onset : From birth
Frequency : Not available
Gene involved : SILV
Tested mutation : SINE insertion
Transmission : Autosomal Dominant
Patent : -
Notes :
Loss of vision
Description: Abnormal development of the choroid (a layer of tissue under the retina of the eye)
Symptoms : Variability of clinical signs according to the breed and individuals: - grade 1 and 2: mild form, without disablement and evolution - grade 3 and 4: severe form with retinal detachment and intraocular haemorrhage, might cause blindness
Age of onset : From the age of 8 weeks
Frequency : Not available
Gene involved : NHEJ1
Tested mutation : c.588+462_588+8260del7799bp
Transmission : Autosomal Recessive
Patent : _
Notes : Mild and severe forms being due to a single mutation in the same gene, dogs with a mild form may produce offspring presenting a severe form.
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ANTAGENE produces an unique genetic fingerprint of a dog or a cat
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten