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Nervous system degeneration
Description: Cerebellum degeneration with neuronal ceroid lipofuscinosis leading to nervous system disorders.
Symptoms : "Wobbly" gait, tremors, incoordination, loss of balance. At the final stage, the dog is unable to move and euthanasia is generally practiced
Age of onset : Between 3 and 5 years old
Frequency : -
Gene involved : ARSG
Tested mutation : c.296G>A
Transmission : Autosomal Recessive
Patent : ANTAGENE Worldwide License
Notes :
Predisposition to urate bladder stones
Description: Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones
Symptoms : Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder
Age of onset : Between 3 and 6 years old
Frequency :
Gene involved : SLC2A9
Tested mutation : c.616G>T
Transmission : Autosomal Recessive
Patent : _
Notes : Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.
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