ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Lens displacement in the eye
Description: Partial or complete breakdown of the zonular ligaments suspending the lens
Symptoms : Reddened eye, pain, corneal oedema, glaucoma which can damage the optic nerve causing blindness
Age of onset : Between 3 and 8 years old
Frequency : 40%
Gene involved : ADAMTS17
Tested mutation : c.1473+1G>A
Transmission : Autosomal Recessive
Patent : _
Notes : Primary lens luxation affects both eyes although few weeks or few months can separate luxation from each eye. Some clinical cases are not associate with the mutation.
Skin lesions and poor growth
Description: Dermatosis characterized by poor growth, immune deficiency, and skin lesions, especially at the paws and in the face
Symptoms : Skin lesions (erythema, tightly adherent scale with crust) at the feet, elbows, hocks and muzzle, failure to thrive, immunodeficiency, skin infections. Later on, hyperkeratosis of the footpads and degeneration of the nails. Affected puppies typically die before they reach an age of two years, either due to infections or euthanasia when their foot lesions become very severe and painful.
Age of onset : From birth
Frequency : 27% carriers in French population
Gene involved : -
Tested mutation : -
Transmission : Autosomal Recessive
Patent : -
Notes : -
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Tail chasing
Speciality Neurology
Description : Disease classified as an obsessive compulsive disorder. Current hypothesis: syndrome suggested to resemble partial seizures (without loss of consciousness) during which an abnormal electrical activity occurs in the temporal lobe of the brain (brain area involved in behaviour).
Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail. Some cases may be associated with aggressiveness which is triggered without reason and/or growling against a person or an object, irrational fears or disorders of consciousness with an apparent disassociation of the environment (trance-like behaviour, hallucinatory fly-catching compulsions...).
Age of onset : Puppies can be affected as early as few months, but the hormonal changes at puberty appear to be involved in the onset or worsening of this disorder.
Examination : Neurological check-up
Progress : Undergoing sampling. The first genetic results would show a genetically complex disorder.
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist and team of Dr H. Lohi (University of Helsinki, Finland)
Contact : spinning@vetagro-sup.fr mageane@antagene.com
Comment : Your involvement in research is essential to our progress.
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Speciality Neurology
Description : Unilateral or bilateral deafness. Deafness is easily diagnosed only when it is bilateral. In case of unilateral deafness, the anomaly is sometimes detected only by the BAER test.
Symptoms : -
Age of onset : From birth
Examination : Brainstem auditory-evoked response (BAER)
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : -
Contact : mageane@antagene.com
Comment : -