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Miniature American Shepherd
Miniature American Shepherd
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
MDR1 - Multidrug Sensitivity
Poisoning after drug admission
Miniature American Shepherd
MDR1 - Multidrug Sensitivity
Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs
Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death
Age of onset : From birth
Frequency : Not available
Gene involved : MDR1
Tested mutation : c.227_230delATAG
Transmission : Autosomal Codominant
Patent : VHL Licence
Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.
HSF4-A - Hereditary Cataract
Lens opacity and blindness
Miniature American Shepherd
HSF4-A - Hereditary Cataract
Description: Lens opacity which affect both eyes (not obligatory at the same time)
Symptoms : Observation of two different cataracts in this breed: - mild, early-onset, seldom leading to loss of vision - severe, may affect vision
Age of onset : -
Frequency : Not available
Gene involved : HSF4
Tested mutation : g.85286582delC
Transmission : Autosomal Codominant
Patent : -
Notes : Heterozygotes may have the mild form, homozygous mutated dogs mainly develop the severe form.
CEA - Collie Eye Anomaly (Choroidal Hypoplasia - Optigen payment 130$)
Loss of vision
Miniature American Shepherd
CEA - Collie Eye Anomaly (Choroidal Hypoplasia - Optigen payment 130$)
Description: Abnormal development of the choroid (a layer of tissue under the retina of the eye)
Symptoms : Variability of clinical signs according to the breed and individuals: - grade 1 and 2: mild form, without disablement and evolution - grade 3 and 4: severe form with retinal detachment and intraocular haemorrhage, might cause blindness
Age of onset : From the age of 8 weeks
Frequency : Not available
Gene involved : NHEJ1
Tested mutation : c.588+462_588+8260del7799bp
Transmission : Autosomal Recessive
Patent : _
Notes : Mild and severe forms being due to a single mutation in the same gene, dogs with a mild form may produce offspring presenting a severe form.
PRA-prcd - Progressive Retinal Atrophy (Optigen payment 130$)
Progressive loss of vision
Miniature American Shepherd
PRA-prcd - Progressive Retinal Atrophy (Optigen payment 130$)
Description: Progressive rod-cone degeneration
Symptoms : Declining vision (at night and then in daylight) and eventual blindness
Age of onset : Between 2 and 12 years old
Frequency : Not available
Gene involved : PRCD
Tested mutation : c.5G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
CMR1 - Multifocal Retinopathy
Retinal detachments
Miniature American Shepherd
CMR1 - Multifocal Retinopathy
Description: Retinal pigment epithelial dysplasia causing localized multifocal retinal detachments
Symptoms : In the mild form, no vision disorders are reported despite the abnormal retina. In the severe form, lesions can lead to blindness
Age of onset : Before 4 months old
Frequency : Not available
Gene involved : BEST1
Tested mutation : c.73C>T
Transmission : Autosomal Recessive
Patent : _
Notes : _
DM - Degenerative Myelopathy
Progressive paralysis
Miniature American Shepherd
DM - Degenerative Myelopathy
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
HUU - Hyperuricosuria
Predisposition to urate bladder stones
Miniature American Shepherd
HUU - Hyperuricosuria
Description: Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones
Symptoms : Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder
Age of onset : Between 3 and 6 years old
Frequency :
Gene involved : SLC2A9
Tested mutation : c.616G>T
Transmission : Autosomal Recessive
Patent : _
Notes : Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.
QC - Short Tail
Presence of a naturally shortened tail
Miniature American Shepherd
QC - Short Tail
Description: DNA test can identifying dogs carrying the phenotype "Natural Bobtail"
Symptoms : Shortened tail, variability according to individuals: missing tail to 3/4 of tail length
Age of onset : _
Frequency : _
Gene involved : T
Tested mutation : c.295C>G
Transmission : Autosomal Dominant
Patent : _
Notes : _
MERLE - Merle Coat Colour
M locus
Miniature American Shepherd
MERLE - Merle Coat Colour
Description: DNA test can identify dogs carrying the genotype "Merle" (M Locus) and highlight double merles and cryptic merles
Symptoms : Patches of diluted pigment intermingled with normal melanin, blue eyes, often associated with a wide range of auditory and ophthalmologic abnormalities. Double merles are predominantly white
Age of onset : From birth
Frequency : Not available
Gene involved : SILV
Tested mutation : SINE insertion
Transmission : Autosomal Dominant
Patent : -
Notes :
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat