Language :
Laekenois
Laekenois
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
SDCA1 - Spongy Degeneration with Cerebellar Ataxia
Nervous system degeneration
Laekenois
SDCA1 - Spongy Degeneration with Cerebellar Ataxia
Description: Cerebellar dysfunction
Symptoms : Wide-based ataxic gait (more obvious in the hind limbs), exagerated gait movements, seizures, run into obstacles. Rapid and severe progression of clinical signs. Less consistent: stumbling, staggering, intention tremor, bunny hopping, balance loss, falling and decelerated eye ball coordination during fast head motion. Muscle spasms and aggravation of cerebellar symptoms after stress or exercise
Age of onset : Between 4 and 9 weeks old
Frequency : Not available
Gene involved : KCNJ10
Tested mutation : c.986T>C
Transmission : Autosomal Recessive
Patent : -
Notes :
SDCA2 - Spongy Degeneration with Cerebellar Ataxia
Nervous system degeneration
Laekenois
SDCA2 - Spongy Degeneration with Cerebellar Ataxia
Description: Cerebellar dysfunction
Symptoms : Generalized ataxic gait, pacing, circling, inability to ambulate, seizures, central blindness. Rapid and severe progression of clinical signs.
Age of onset : Between 4 and 6 weeks old
Frequency : Not available
Gene involved : ATP1B2
Tested mutation : c.130_131ins227
Transmission : Autosomal Recessive
Patent : -
Notes : -
DM - Degenerative Myelopathy
Progressive paralysis
Laekenois
DM - Degenerative Myelopathy
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
DIL - Dilution (D Locus)
Lighter black or brown coat colour
Laekenois
DIL - Dilution (D Locus)
Description: DNA test can identifying dogs carrying the genotype "Dilute" (D Locus)
Symptoms : Dilution or lightening effect of the black or brown colours
Age of onset : From birth
Frequency : _
Gene involved : MLPH
Tested mutation : c.-22G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
PL - Hair Length
Long coat / Short coat
Laekenois
PL - Hair Length
Description: DNA test can identifying dogs carrying the genotype "Long Coat"
Symptoms : _
Age of onset : _
Frequency : -
Gene involved : FGF5
Tested mutation : c.284G>T
Transmission : Autosomal Recessive
Patent : _
Notes : _
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat