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Labrador Retriever
Labrador Retriever
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
CNM - Centronuclear Myopathy
Early muscular atrophy
Labrador Retriever
CNM - Centronuclear Myopathy
Description: Atrophy of muscle fibres due to myofibres remodelling
Symptoms : Muscle weakness, exercise intolerance. Onset of progressive weight loss by 15 days old
Age of onset : Between 2 and 5 months old
Frequency : Lower than 5% carriers
Gene involved : PTPLA
Tested mutation : c.191_192ins236b
Transmission : Autosomal Recessive
Patent : _
Notes : For more information: www.labradorcnm.com
SD2 - Skeletal Dysplasia 2
Dwarfism
Labrador Retriever
SD2 - Skeletal Dysplasia 2
Description: Abnormality of skeletal development leading to mild disproportionate dwarfism
Symptoms : Short legs with normal body length and width, lower shoulder height (< 50 cm) compared to the international breed standard (54-57 cm), not affecting health condition
Age of onset : -
Frequency : Not available
Gene involved : COL11A2
Tested mutation : c.143G>C
Transmission : Autosomal Recessive
Patent : -
Notes :
PRA-prcd - Progressive Retinal Atrophy (partner laboratory 90€)
Progressive loss of vision
Labrador Retriever
PRA-prcd - Progressive Retinal Atrophy (partner laboratory 90€)
Description: Progressive rod-cone degeneration
Symptoms : Declining vision (at night and then in daylight) and eventual blindness
Age of onset : Between 1,5 and 6 years old
Frequency : 23% carriers in European population
Gene involved : PRCD
Tested mutation : c.5G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
COUL-2 - B Locus + E Locus
Presence of brown or yellow coat
Labrador Retriever
COUL-2 - B Locus + E Locus
Description: DNA test can identifying dogs carrying the genotype "Brown" (Locus B) and the genotype "Yellow" (E Locus)
Symptoms : _
Age of onset : _
Frequency : _
Gene involved : TYRP1 and MC1R
Tested mutation : TYRP1: S41C, Q331X and 345delPMC1R: R306X
Transmission : Autosomal
Patent : _
Notes : _
PL - Hair Length
Long coat / Short coat
Labrador Retriever
PL - Hair Length
Description: DNA test can identifying dogs carrying the genotype "Long Coat"
Symptoms : -
Age of onset : -
Frequency : -
Gene involved : FGF5
Tested mutation : c.284G>T
Transmission : Autosomal Recessive
Patent : -
Notes : -
DIL - Dilution (D Locus)
Lighter black or brown coat colour
Labrador Retriever
DIL - Dilution (D Locus)
Description: DNA test can identifying dogs carrying the genotype "Dilute" (D Locus)
Symptoms : Dilution or lightening effect of the black or brown colours
Age of onset : From birth
Frequency : _
Gene involved : MLPH
Tested mutation : c.-22G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Melanoma
Pigment cell cancer
Labrador Retriever
Melanoma
Speciality Oncology
Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites
Symptoms : -
Age of onset : -
Examination : Histological or cytological analyses
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. André (CNRS of Rennes, France)
Contact : cani-dna@univ-rennes1.fr mageane@antagene.com
Comment : -
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Melanoma
Pigment cell cancer
Labrador Retriever
Melanoma
Speciality Oncology
Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites
Symptoms : -
Age of onset : -
Examination : Histological or cytological analyses
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. André (CNRS of Rennes, France)
Contact : cani-dna@univ-rennes1.fr mageane@antagene.com
Comment : -