Kromfohrlander

HFH-A - Hereditary Footpad Hyperkeratosis

Corny Feet

Description: Thickening and hardening of footpads resulting from abnormal proliferation of epidermal cells.

Symptoms : Horny protrusions on all footpads, fissures and cracks possibly causing great pain and therefore reduced mobility of the dog. In some cases, nail growth problem, alteration of hair morphology.

Age of onset : Between 4 and 9 months old

Frequency : 34% carriers

Gene involved :

Tested mutation :

Transmission : Autosomal Recessive

Patent :

Notes : The research was led by the team of Prof. Tosso Leeb (University of Bern) in collaboration with Antagene.

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Kromfohrlander

VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation

Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases

Age of onset : From birth

Frequency : Not available

Gene involved : VWF

Tested mutation : c.7142C>T

Transmission : Autosomal Recessive

Patent : _

Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs

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