ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Predisposition to urate bladder stones
Description: Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones
Symptoms : Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder
Age of onset : Between 3 and 6 years old
Frequency :
Gene involved : SLC2A9
Tested mutation : c.616G>T
Transmission : Autosomal Recessive
Patent : _
Notes : Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.
Lens displacement in the eye
Description: Partial or complete breakdown of the zonular ligaments suspending the lens
Symptoms : Reddened eye, pain, corneal oedema, glaucoma which can damage the optic nerve causing blindness
Age of onset : Between 3 and 8 years old
Frequency : 27%
Gene involved : ADAMTS17
Tested mutation : c.1473+1G>A
Transmission : Autosomal Recessive
Patent : _
Notes : Primary lens luxation affects both eyes although few weeks or few months can separate luxation from each eye. Some clinical cases are not associate with the mutation.
Presence of a naturally shortened tail
Description: DNA test can identifying dogs carrying the phenotype "Natural Bobtail"
Symptoms : Shortened tail, variability according to individuals: missing tail to 3/4 of tail length
Age of onset : _
Frequency : _
Gene involved : T
Tested mutation : c.295C>G
Transmission : Autosomal Dominant
Patent : _
Notes : _
Nervous system degeneration
Description: Nervous system degeneration with or without myokymia and seizures
Symptoms : Progressive loss of limb coordination, spastic gait, loss of balance, could be combined with seizures and myokymia (involuntary twitching of the muscles)
Age of onset : Between 2 and 6 months old
Frequency : Lower than 5% carriers
Gene involved : KCNJ10
Tested mutation : c.627C>G
Transmission : Autosomal Recessive
Patent : -
Notes : An another DNA test (LOA) is available to detect an other form of ataxia in this breed.
Nervous system degeneration
Description: Nervous system degeneration
Symptoms : Progressive loss of limb coordination, spastic gait, loss of balance, difficulty in jumping
Age of onset : Between 6 and 12 months old
Frequency : Lower than 5% carriers
Gene involved : CAPN1
Tested mutation : c.344G>A
Transmission : Autosomal Recessive
Patent : -
Notes : An another DNA test (SCA) is available to detect an other form of ataxia in this breed.
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Tail chasing
Speciality Neurology
Description : Disease classified as an obsessive compulsive disorder
Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.
Age of onset : -
Examination : Neurological check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist
Contact : spinning@vetagro-sup.fr mageane@antagene.com
Comment : -
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Tail chasing
Speciality Neurology
Description : Disease classified as an obsessive compulsive disorder
Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.
Age of onset : -
Examination : Neurological check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist
Contact : spinning@vetagro-sup.fr mageane@antagene.com
Comment : -