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Jack Russell Terrier
Jack Russell Terrier
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
HUU - Hyperuricosuria
Predisposition to urate bladder stones
Jack Russell Terrier
HUU - Hyperuricosuria
Description: Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones
Symptoms : Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder
Age of onset : Between 3 and 6 years old
Frequency :
Gene involved : SLC2A9
Tested mutation : c.616G>T
Transmission : Autosomal Recessive
Patent : _
Notes : Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.
PLL-A - Primary Lens Luxation
Lens displacement in the eye
Jack Russell Terrier
PLL-A - Primary Lens Luxation
Description: Partial or complete breakdown of the zonular ligaments suspending the lens
Symptoms : Reddened eye, pain, corneal oedema, glaucoma which can damage the optic nerve causing blindness
Age of onset : Between 3 and 8 years old
Frequency : 27%
Gene involved : ADAMTS17
Tested mutation : c.1473+1G>A
Transmission : Autosomal Recessive
Patent : _
Notes : Primary lens luxation affects both eyes although few weeks or few months can separate luxation from each eye. Some clinical cases are not associate with the mutation.
QC - Short Tail
Presence of a naturally shortened tail
Jack Russell Terrier
QC - Short Tail
Description: DNA test can identifying dogs carrying the phenotype "Natural Bobtail"
Symptoms : Shortened tail, variability according to individuals: missing tail to 3/4 of tail length
Age of onset : _
Frequency : _
Gene involved : T
Tested mutation : c.295C>G
Transmission : Autosomal Dominant
Patent : _
Notes : _
SCA - Spinocerebellar Ataxia
Nervous system degeneration
Jack Russell Terrier
SCA - Spinocerebellar Ataxia
Description: Nervous system degeneration with or without myokymia and seizures
Symptoms : Progressive loss of limb coordination, spastic gait, loss of balance, could be combined with seizures and myokymia (involuntary twitching of the muscles)
Age of onset : Between 2 and 6 months old
Frequency : Lower than 5% carriers
Gene involved : KCNJ10
Tested mutation : c.627C>G
Transmission : Autosomal Recessive
Patent : -
Notes : An another DNA test (LOA) is available to detect an other form of ataxia in this breed.
LOA - Late Onset Ataxia
Nervous system degeneration
Jack Russell Terrier
LOA - Late Onset Ataxia
Description: Nervous system degeneration
Symptoms : Progressive loss of limb coordination, spastic gait, loss of balance, difficulty in jumping
Age of onset : Between 6 and 12 months old
Frequency : Lower than 5% carriers
Gene involved : CAPN1
Tested mutation : c.344G>A
Transmission : Autosomal Recessive
Patent : -
Notes : An another DNA test (SCA) is available to detect an other form of ataxia in this breed.
IC - Improper Coat - Furnishings
Type of coat
Jack Russell Terrier
IC - Improper Coat - Furnishings
Description: DNA test can identifying dogs carrying the trait smooth coat without furnishings also called improper coat in some breeds
Symptoms : Short hair on the head and face, as well as on lower legs
Age of onset : From birth
Frequency : Not available
Gene involved : RSPO2
Tested mutation : 167pb insertion
Transmission : Autosomal Recessive
Patent : -
Notes :
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Spinning
Tail chasing
Jack Russell Terrier
Spinning
Speciality Neurology
Description : Disease classified as an obsessive compulsive disorder
Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.
Age of onset : -
Examination : Neurological check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist
Contact : spinning@vetagro-sup.fr mageane@antagene.com
Comment : -
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Spinning
Tail chasing
Jack Russell Terrier
Spinning
Speciality Neurology
Description : Disease classified as an obsessive compulsive disorder
Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.
Age of onset : -
Examination : Neurological check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist
Contact : spinning@vetagro-sup.fr mageane@antagene.com
Comment : -