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Golden Retriever
Golden Retriever
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
ICT-A - Ichthyosis
Overabundance of dandruffs
Golden Retriever
ICT-A - Ichthyosis
Description: The mutated gene is involved in the skin barrier lipid metabolism, its dysfunction leads to an abnormal desquamation
Symptoms : Large-sized dandruffs whitish then blackish, mainly on the trunk and particularly visible on the belly. In the worst forms, complications (bacterial, fungal or parasitic) are observed
Age of onset : Between 1 and 18 months old
Frequency : European population: 83% carriers ; American population: 61% carriers ; Australian population: 52% carriers
Gene involved : PNPLA1
Tested mutation : Indel in exon 8
Transmission : Autosomal Recessive
Patent : ANTAGENE Worldwide exclusive License
Notes : This DNA test is the result of researches and efforts to improve the health of purebreed dogs and cats. Only ANTAGENE masters the performing process of these DNA tests to garantee a 99.9% accuracy of the results delivered Legal mention : ICT-A test : CNRS-Rennes 1 patent ANTAGENE License
GR-PRA1 - Progressive Retinal Atrophy
Progressive loss of vision
Golden Retriever
GR-PRA1 - Progressive Retinal Atrophy
Description: Progressive rod-cone degeneration
Symptoms : Progressive loss of vision (at night and then in daylight) culminating in blindness
Age of onset : Between 6 and 7 years old
Frequency : 4% carriers in French population - 8% carriers in English population
Gene involved : SLC4A3
Tested mutation : c.2601_2602insC
Transmission : Autosomal Recessive
Patent : -
Notes : Another DNA test (PRA-prcd) is available to detect another form of PRA in this breed.
NCL-F - Neuronal Ceroid Lipofuscinosis
Nervous system degeneration
Golden Retriever
NCL-F - Neuronal Ceroid Lipofuscinosis
Description: Neurodegenerative disease leading to loss of motor function and vision and to behavioural disorder
Symptoms : Progressive loss of motor function and coordination (ataxia), visual impairment, behavioural disorder, anxiety, aggression, tremors, localized and generalized seizures
Age of onset : Between 12 and 18 months old
Frequency : Not available
Gene involved : CLN5
Tested mutation : c.934_935delAG
Transmission : Autosomal Recessive
Patent : -
Notes :
DEB - Dystrophic Epidermolysis Bullosa
Cutaneous lesions
Golden Retriever
DEB - Dystrophic Epidermolysis Bullosa
Description: Abnormal collagen protein leading to separation of the epidermis from the underlying dermis
Symptoms : Blistering and ulcerations of the skin and inside the mouth and in the esophagus, growth retardation, nails dystrophy
Age of onset : From birth
Frequency : Lower than 1% carriers
Gene involved : COL7A1
Tested mutation : c.5716G>A
Transmission : Autosomal Recessive
Patent : -
Notes :
PRA-prcd - Progressive Retinal Atrophy (Optigen payment 130$)
Progressive loss of vision
Golden Retriever
PRA-prcd - Progressive Retinal Atrophy (Optigen payment 130$)
Description: Progressive rod-cone degeneration
Symptoms : Declining vision (at night and then in daylight) and eventual blindness
Age of onset : Between 2 and 12 years old
Frequency : Not available
Gene involved : PRCD
Tested mutation : c.5G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
SH - Histiocytic sarcoma
Immune cancer
Golden Retriever
SH - Histiocytic sarcoma
Speciality Oncology
Description : Tumour affecting histiocytes, cells responsible for immune function. Development of tumours spread throughout several organs (spleen, lungs, liver, lymph nodes…)
Symptoms : Weight loss, lethargy, anorexia, occasionally fever, cough and pale mucous membranes
Age of onset : The average age of detection is 6.5 years
Examination : Histological or cytological analyses
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. André (CNRS of Rennes, France). http://dog-genetics.genouest.org/index.php?option=com_content&view=article&id=9&Itemid=17&lang=en
Contact : cani-dna@univ-rennes1.fr mageane@antagene.com
Comment : -
Melanoma
Pigment cell cancer
Golden Retriever
Melanoma
Speciality Oncology
Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites
Symptoms : -
Age of onset : -
Examination : Histological or cytological analyses
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. André (CNRS of Rennes, France)
Contact : cani-dna@univ-rennes1.fr mageane@antagene.com
Comment : -
Ectopic Ureter
Malformation leading to urinary incontinence
Golden Retriever
Ectopic Ureter
Speciality Urology
Description : Defect of embryonic development resulting in abnormally located terminal portion of the ureter
Symptoms : Urinary leakage, affects males and females but is more observable in females
Age of onset : From birth
Examination : Intravenous urography, echography
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : -
Contact : mageane@antagene.com
Comment : -
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
SH - Histiocytic sarcoma
Immune cancer
Golden Retriever
SH - Histiocytic sarcoma
Speciality Oncology
Description : Tumour affecting histiocytes, cells responsible for immune function. Development of tumours spread throughout several organs (spleen, lungs, liver, lymph nodes…)
Symptoms : Weight loss, lethargy, anorexia, occasionally fever, cough and pale mucous membranes
Age of onset : The average age of detection is 6.5 years
Examination : Histological or cytological analyses
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. André (CNRS of Rennes, France) http://dog-genetics.genouest.org/index.php?option=com_content&view=article&id=9&Itemid=17&lang=en
Contact : cani-dna@univ-rennes1.fr mageane@antagene.com
Comment : -
Melanoma
Pigment cell cancer
Golden Retriever
Melanoma
Speciality Oncology
Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites
Symptoms : -
Age of onset : -
Examination : Histological or cytological analyses
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : Dr C. André (CNRS of Rennes, France)
Contact : cani-dna@univ-rennes1.fr mageane@antagene.com
Comment : -
Ectopic Ureter
Malformation leading to urinary incontinence
Golden Retriever
Ectopic Ureter
Speciality Urology
Description : Defect of embryonic development resulting in abnormally located terminal portion of the ureter
Symptoms : Urinary leakage, affects males and females but is more observable in females
Age of onset : From birth
Examination : Intravenous urography, echography
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : -
Contact : mageane@antagene.com
Comment : -