Czechoslovakian Wolfdog

NAH - Pituitary Dwarfism

Growth retardation

Description: Underdevelopment of the pituitary gland leading to pituitary hormone deficiency causing growth retardation

Symptoms : Marked growth retardation, small size, retention of puppy coat, lack of adult coat, bilateral symetrical loss of hair coat mostly located at the trunk, the neck and at the top of the legs Less frequent signs : hyperpigmentation of the skin, scales, bacterial infections

Age of onset : Significated clinical signs 2-3 months after birth

Frequency : 7% carriers in French population

Gene involved : LHX3

Tested mutation : 7bp del intron 5 affects splice site

Transmission : Autosomal Recessive

Patent : -

Notes : -

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Czechoslovakian Wolfdog

DM - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : _

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : _

Notes :

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Czechoslovakian Wolfdog

PL - Hair Length

Long coat / Short coat

Description: DNA test can identifying dogs carrying the genotype "Long Coat"

Symptoms : _

Age of onset : _

Frequency : -

Gene involved : FGF5

Tested mutation : c.284G>T

Transmission : Autosomal Recessive

Patent : _

Notes : _

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