ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Inability to move
Description: Nervous system degeneration
Symptoms : Disorders of the balance with an incapacity to coordinate movements, inability to walk or to remain standing
Age of onset : From birth
Frequency : European population: 9% carriers ; American population: 13% carriers
Gene involved : GRM1
Tested mutation : retrotransposon insertion
Transmission : Autosomal Recessive
Patent : _
Notes : _
Retinal detachments
Description: Retinal pigment epithelial dysplasia causing localized multifocal retinal detachments
Symptoms : In the mild form, no vision disorders are reported despite the abnormal retina. In the severe form, lesions can lead to blindness
Age of onset : Before 4 months old
Frequency : 27%
Gene involved : BEST1
Tested mutation : c.482G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
Mild bleeding disorder
Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation
Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases
Age of onset : From birth
Frequency : Not available
Gene involved : VWF
Tested mutation : c.7142C>T
Transmission : Autosomal Recessive
Patent : _
Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs
Progressive paralysis
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Lens opacity and blindness
Speciality Ophthalmology
Description : Anterior and/or posterior subcapsular cataract
Symptoms : Partial or complete bilateral lens opacity causing visual impairment
Age of onset : Between 3 and 5 years old
Examination : Ophthalmic check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : -
Contact : mageane@antagene.com
Comment : -
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Lens opacity and blindness
Speciality Ophthalmology
Description : Anterior and/or posterior subcapsular cataract
Symptoms : Partial or complete bilateral lens opacity causing visual impairment
Age of onset : Between 3 and 5 years old
Examination : Ophthalmic check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : -
Contact : mageane@antagene.com
Comment : -