Language :
Coton de Tulear
Coton de Tulear
Antagene Séléction
DNA - based testing for hereditary diseases
ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
BNAT - Neonatal Ataxia
Inability to move
Coton de Tulear
BNAT - Neonatal Ataxia
Description: Nervous system degeneration
Symptoms : Disorders of the balance with an incapacity to coordinate movements, inability to walk or to remain standing
Age of onset : From birth
Frequency : European population: 9% carriers ; American population: 13% carriers
Gene involved : GRM1
Tested mutation : retrotransposon insertion
Transmission : Autosomal Recessive
Patent : _
Notes : _
CMR2 - Multifocal Retinopathy
Retinal detachments
Coton de Tulear
CMR2 - Multifocal Retinopathy
Description: Retinal pigment epithelial dysplasia causing localized multifocal retinal detachments
Symptoms : In the mild form, no vision disorders are reported despite the abnormal retina. In the severe form, lesions can lead to blindness
Age of onset : Before 4 months old
Frequency : 27%
Gene involved : BEST1
Tested mutation : c.482G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
VWD1 - von Willebrand's Disease Type I
Mild bleeding disorder
Coton de Tulear
VWD1 - von Willebrand's Disease Type I
Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation
Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases
Age of onset : From birth
Frequency : Not available
Gene involved : VWF
Tested mutation : c.7142C>T
Transmission : Autosomal Recessive
Patent : _
Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs
DM - Degenerative Myelopathy
Progressive paralysis
Coton de Tulear
DM - Degenerative Myelopathy
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
Antagene Parenté
DNA - Certified parentage
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
Antagene Identité
Genetic Identification
ANTAGENE produces an unique genetic fingerprint of a dog or a cat
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Hereditary Cataract
Lens opacity and blindness
Coton de Tulear
Hereditary Cataract
Speciality Ophthalmology
Description : Anterior and/or posterior subcapsular cataract
Symptoms : Partial or complete bilateral lens opacity causing visual impairment
Age of onset : Between 3 and 5 years old
Examination : Ophthalmic check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : -
Contact : mageane@antagene.com
Comment : -
Programme de recherche
Research program
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Hereditary Cataract
Lens opacity and blindness
Coton de Tulear
Hereditary Cataract
Speciality Ophthalmology
Description : Anterior and/or posterior subcapsular cataract
Symptoms : Partial or complete bilateral lens opacity causing visual impairment
Age of onset : Between 3 and 5 years old
Examination : Ophthalmic check-up
Progress : Undergoing sampling
Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)
Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree
Collaboration : -
Contact : mageane@antagene.com
Comment : -