Continental Toy Spaniel Papillon

VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation

Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases

Age of onset : From birth

Frequency : Not available

Gene involved : VWF

Tested mutation : c.7142C>T

Transmission : Autosomal Recessive

Patent : _

Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs

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Continental Toy Spaniel Papillon

pap-PRA1 - Progressive Retinal Atrophy

Progressive loss of vision

Description: Progressive rod-cone degeneration

Symptoms : Progressive loss of vision (at night and then in daylight) culminating in blindness. Many affected dogs maintain daylight vision for many years, sometimes for the remainder of their life

Age of onset : Between 5 and 6 years old

Frequency : 17% carriers

Gene involved : CNGB1

Tested mutation : c.2685delA2687_2688insTAGCTA

Transmission : Autosomal Recessive

Patent : -

Notes :

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