ANTAGENE provides a certificate displaying the genetic status of a dog or a cat
Lens displacement in the eye
Description: Partial or complete breakdown of the zonular ligaments suspending the lens
Symptoms : Reddened eye, pain, corneal oedema, glaucoma which can damage the optic nerve causing blindness
Age of onset : Between 3 and 8 years old
Frequency : Not available
Gene involved : ADAMTS17
Tested mutation : c.1473+1G>A
Transmission : Autosomal Recessive
Patent : _
Notes : Primary lens luxation affects both eyes although few weeks or few months can separate luxation from each eye.
Progressive paralysis
Description: Degenerative disease of the spinal cord causing progressive paralysis
Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Age of onset : Between 8 and 14 years old
Frequency : _
Gene involved : SOD1
Tested mutation : c.118G>A
Transmission : Autosomal Recessive
Patent : _
Notes :
Mild bleeding disorder
Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation
Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases
Age of onset : From birth
Frequency : Not available
Gene involved : VWF
Tested mutation : c.7142C>T
Transmission : Autosomal Recessive
Patent : _
Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs
Progressive loss of vision
Description: Progressive rod-cone degeneration
Symptoms : Declining vision (at night and then in daylight) and eventual blindness
Age of onset : Between 2 and 12 years old
Frequency : Not available
Gene involved : PRCD
Tested mutation : c.5G>A
Transmission : Autosomal Recessive
Patent : _
Notes : _
ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten
ANTAGENE produces an unique genetic fingerprint of a dog or a cat