Spinal Muscular Atrophy (SMA)

The Spinal Muscular Atrophy (SMA) is a neuromuscular inherited disease. This affection is a degenerative problem that affects the spinal cord neurons, activating skeletal muscles of the trunk and limbs. Loss of neurons in the first few months of life leads to muscle weakness and atrophy that first becomes apparent at 3-4 months of age. Some affected kittens could live relatively comfortably until their 9 years.

The SMA is inherited as a an autosomal recessive trait in the Maine Coon.


ANTAGENE offers a DNA test for SMA screening in The Maine Coon.
 
Pr John Fyfe from the University of Michigan (USA) identified the gene and the mutation causing SMA in Maine Coon (Fyfeet al. 2006). In collaboration with Pr John Fyfe, ANTAGENE developped DNA test and validated it on carriers and affected Maine Coon.

The SMA test detects directly the causative mutation in the LIX1 gene.


The frequency of carriers Maine Coon is among 1% and 5%. We recommend consultation of affected kittens with a veterinarian to follow the progression of the disease. Using this DNA test, breeders avoid equally to spread the genetic defect in their lines or in the breed.


Why to test your cat ?
• to detect very early carrier cat
• to select breeding animals and to adapt breeding strategies
• to avoid producing and selling kitten affected by
• to anticipate the apparition of the disease