The
hypertrophic cardiomyopathy, known as HCM, is a disease affecting cats in which the walls of the heart become increasingly enlarged.
Symptoms are: lethargy, poor appetite, troubled breathing. The hypertrophic cardiomyopathy appears between 4 months and 15 years and even without serious symptoms the disease progression observed in affected cats causes the untimely death of the animal.
The HCM disease is monogenic and is transmitted in an autosomal dominant pattern.
ANTAGENE proposes a DNA test to detect the HCM disease in
Maine Coon.
This disease affects also other breeds of cat. ANTAGENE began in 2005 a research program to detect the gene or genes implied in the HCM disease in these various breeds. For further information, please feel free to contact us.The DNA test detects a mutation within the MYBPC3 gene (HCM1 form). The HCM test detects only this HCM1 form and only in Maine Coon's breed.
In collaboration with the Alfort Veterinary School, veterinarian specialized in cardiology and Maine Coon's breeders, the Laboratory ANTAGENE began a clinical and genetic study from March to November 2006 on HCM in Maine Coon. This study emphasizes that:
• 42% of Maine Coon carry this mutation (38% heterozygous, 4% homozygous)
• 14% of Maine Coon show clinical signs on ecocardiography before their 3 years old
• few clinical data are given for cats over 3 years old
Why to test your cat ?
• to detect very early carrier cat
• to select breeding animals and to adapt breeding strategies
• to avoid producing and selling kitten affected by
• to anticipate the apparition of the disease
• to apply certain preventive treatments in order to delay and to limit the development of the renal insufficiency
The HCM1 form is expressed according to an autosomal dominant mode, with nevertheless a great variability of expression and probably an incomplete penetrance. The DNA test does not indicate the age of appearance and netheir the gravity of the symptoms. Consult your vet or a a veterinarian specialized in cardiology.
