The cystinuria is a genetic disease due to the accumulation of cystine in kidney, which may further precipitate to form calculi (stones) in the kidney and bladder. These calculi can cause serious illness including complete urinary blockage, which is a medical emergency.
Cystinuric dogs often show signs of recurrent urinary tract disorder.
Clinical signs may start at almost any age. In Newfoundland dog, affected animals show clinical signs of illness as early as 6 months of age.
They may produce blood-tinged urine and pass calculi, or they may be unable to avoid urine despite numerous attempts.
The cystinuria is inherited as an autosomal recessive trait in the Newfoundland dog.
ANTAGENE proposes a DNA test to detect the cystinuria in following breeds :
• Newfoundland
• Landseer
About 20% of Newfoundland dogs are carrier of the genetic anomaly responsible for this disease. The carrier dog will not develop this disease but 50% of its progeny will be carrier.
Why to test your dog ?
• to detect very early carrier dog
• to select breeding animals and to adapt breeding strategies
• to avoid producing and selling pups affected by
• to anticipate the apparition of the disease
