Research program

Description: 
ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests
Tests: 

LAD - Lethal Acrodermatitis

Title:
LAD - Lethal Acrodermatitis
Status:
Active
Description: 
Dermatosis occurring especially on extremities. The prognosis is very poor, dogs are often euthanized, if not died, before the age of one year.
Symptomes: 
Skin disease of the face and feet, stunting, splayed digits, eating difficulties, increased susceptibility to microbial infections due to skin lesions and severe immune deficiency. In some dogs over six months of age: inflammation around claws (paronychia), dermatological, respiratory and digestive inflammations, thickening (hyperkeratosis) of footpads, ocular and/or cardiac disorders
Age d'aparition: 
From birth
Examen: 
Histological analyses
Avancement: 
Undergoing sampling
Collaboration: 
Teams of Drs C. André (CNRS of Rennes, France) and S. Küry (INSERM Nantes, France)
Contact: 
mageane@antagene.com
Remarques: 
-
Spécialité: 
Dermatology
Prélèvements pour participer à la recherche: 
Blood sample in EDTA tube (2-4 mL)
Documents à joindre aux prélèvements: 
Clinical certificate, Sampling certificate, Copy of pedigree
Accroche: 
Skin lesions and stunting

NF - Familial Nephropathy

Title:
NF - Familial Nephropathy
Status:
Active
Description: 
Abnormal kidney basement membrane protein and structure
Symptomes: 
Excessive water consumption, excessive urine volume, weight loss, vomiting, diarrhoea, progressive and ultimately fatal renal failure
Age d'aparition: 
Variable age
Examen: 
Definitive diagnosis can be made only by histological analysis on kidney biopsy or post-mortem sample of kidney.
Avancement: 
Undergoing sampling
Collaboration: 
-
Contact: 
mageane@antagene.com
Remarques: 
-
Spécialité: 
Nephrology
Prélèvements pour participer à la recherche: 
Blood sample in EDTA tube (2-4 mL) In case of death, whatever the reason : • Sample and put promptly a half kidney (sagittal section) in formalin for histological analysis, and a piece of tissue in alcohol (e.g. tongue) for DNA extraction. ANTAGENE cov
Documents à joindre aux prélèvements: 
Clinical certificate, Sampling certificate, Copy of pedigree
Accroche: 
Kidney failure

Spinning

Title:
Spinning
Status:
Active
Description: 
Disease classified as an obsessive compulsive disorder. Current hypothesis: syndrome suggested to resemble partial seizures (without loss of consciousness) during which an abnormal electrical activity occurs in the temporal lobe of the brain (brain area involved in behaviour).
Symptomes: 
Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail. Some cases may be associated with aggressiveness which is triggered without reason and/or growling against a person or an object, irrational fears or disorders of consciousness with an apparent disassociation of the environment (trance-like behaviour, hallucinatory fly-catching compulsions...).
Age d'aparition: 
Puppies can be affected as early as few months, but the hormonal changes at puberty appear to be involved in the onset or worsening of this disorder.
Examen: 
Neurological check-up
Avancement: 
Undergoing sampling. The first genetic results would show a genetically complex disorder.
Collaboration: 
Dr C. Escriou (VetAgro Sup, France), veterinary neurologist and team of Dr H. Lohi (University of Helsinki, Finland)
Contact: 
spinning@vetagro-sup.fr mageane@antagene.com
Remarques: 
Your involvement in research is essential to our progress.
Spécialité: 
Neurology
Prélèvements pour participer à la recherche: 
Blood sample in EDTA tube (2-4 mL)
Documents à joindre aux prélèvements: 
Clinical certificate, Sampling certificate, Copy of pedigree
Accroche: 
Tail chasing
Race liée: 
Bull Terrier