Acral Mutilation Syndrome

 

Acral Mutilation Syndrome leads to lesions on distal extremities caused by self-mutilation.

A reliable DNA test can screen stud dogs and brood bitches, in order to adapt matings and avoid birth of affected puppies and spread of the disease in the breed.

An early and frequent hereditary disease

Acral Mutilation Syndrome leads to lesions on distal extremities caused by self-mutilation, loss of sensitivity to pain on distal limbs may cause a tendency to lick or bite their own pads which could result in an auto-amputation of claws, digits and footpads in severe cases, no limping.

The first symtoms appear between 3 and 12 months old.

A dog « carrier » of the mutation will not develop the disease but transmits it to 50% of the puppies. Breeders unaware of Acral Mutilation Syndrome can mate stud dogs and brood bitches carriers of the mutation and produce puppies affected puppies.

A preventable disease thanks to the AMS DNA test

In order to secure its kennel and avoid the risk of production of affected puppies, the breeder must screen its breeding dogs thanks to the AMS DNA test.

This DNA test is the result of years of research and effort to improve the health of dogs in this breed. The team Genetics Dog CNRS-Université de Rennes I conducted the research that led to the development of this DNA test. Only ANTAGENE controls the process of realization.

This DNA test is a risk test which allows to screen for Acral Mutilation Syndrome for the English Cocker Spaniel, French spaniel, German Pointer, English Springer Spaniel and Pointer.

When acquiring a puppy for breeding or when a stud dog is used for a mating, the breeder verifies the genetic status of the dog for Acral Mutilation Syndrome for the result of the AMS DNA test.

A DNA test easy to perform

The veterinarian performs a simple cheek swab and sends it to the laboratory. The result, delivered within few days, indicates if the tested dog is clear, carrier or affected of Acral Mutilation Syndrome.  A genetic certificate displaying the result must be used as a guarantee for a mating or to justify the sale of puppies clear of Acral Mutilation Syndrome.

A breeder who knows the genetic status of the dog scan select its breeding dogs, adapt matings, avoid the birth of affected puppies and limit the spread of this serious inherited disease in the breed.

 

Somes figures for AMS in the English Cocker Spaniel

ANTAGENE Laboratory