MDR1 - Multidrug Sensitivity/Générique

Poisoning after drug admission

Description: 
Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs
Symptomes: 
hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death
Age d'aparition: 
From birth
Fréquence: 
Not available
Gène impliqué: 
MDR1
Mutation testée: 
c.227_230delATAG
Transmission: 
Autosomal Codominant
Brevet: 
VHL Licence
Remarques: 
For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.