Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones
Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder
Between 3 and 6 years old
Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.