Smooth Collie

Smooth Collie

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Smooth Collie

MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs

Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death

Age of onset : From birth

Frequency : 80%

Gene involved : MDR1

Tested mutation : c.227_230delATAG

Transmission : Autosomal Codominant

Patent : VHL Licence

Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.

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DM - Degenerative Myelopathy

Progressive paralysis

Smooth Collie

DM - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : _

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : _

Notes :

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VWD2 - von Willebrand's Disease Type II

Moderate to severe bleeding disorder

Smooth Collie

VWD2 - von Willebrand's Disease Type II

Moderate to severe bleeding disorder

Description: Low level and abnormal function of von Willebrand factor, a protein involved in blood coagulation

Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal, excessive gingival haemorrhage during eruption of adult teeth, nose bleeding, skin bruising, prolonged bleeding after surgery or trauma

Age of onset : From birth

Frequency : Not available

Gene involved : VWF

Tested mutation : A>G in a2 domain

Transmission : Autosomal Recessive

Patent : -

Notes :

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MERLE - Merle Coat Colour

M locus

Smooth Collie

MERLE - Merle Coat Colour

M locus

Description: DNA test can identify dogs carrying the genotype "Merle" (M Locus) and highlight double merles and cryptic merles

Symptoms : Patches of diluted pigment intermingled with normal melanin, blue eyes, often associated with a wide range of auditory and ophthalmologic abnormalities. Double merles are predominantly white

Age of onset : From birth

Frequency : Not available

Gene involved : SILV

Tested mutation : SINE insertion

Transmission : Autosomal Dominant

Patent : -

Notes :

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CEA - Collie Eye Anomaly (Choroidal Hypoplasia - Optigen payment 130$)

Loss of vision

Smooth Collie

CEA - Collie Eye Anomaly (Choroidal Hypoplasia - Optigen payment 130$)

Loss of vision

Description: Abnormal development of the choroid (a layer of tissue under the retina of the eye)

Symptoms : Variability of clinical signs according to the breed and individuals: - grade 1 and 2: mild form, without disablement and evolution - grade 3 and 4: severe form with retinal detachment and intraocular haemorrhage, might cause blindness

Age of onset : From the age of 8 weeks

Frequency : Not available

Gene involved : NHEJ1

Tested mutation : c.588+462_588+8260del7799bp

Transmission : Autosomal Recessive

Patent : _

Notes : Mild and severe forms being due to a single mutation in the same gene, dogs with a mild form may produce offspring presenting a severe form.

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DMS - Dermatomyositis (Optigen payment 100$)

Skin lesions

Smooth Collie

DMS - Dermatomyositis (Optigen payment 100$)

Skin lesions

Description: Autoimmune disease of the skin and muscle

Symptoms : Hair loss and crusts on face, ear tips, legs and feet, and the tip of the tail. In affected Collies, muscle wasting manifests as atrophy of the head musculature, difficulty eating, drinking, and swallowing and an atypical, high-stepping gait. Muscle involvement is uncommon in Shelties.

Age of onset : Variable (as early as 12 weeks of age or in mature dogs)

Frequency : Not available

Gene involved : PAN2, MAP3K7CL and DLA-DRB1

Tested mutation : PAN2:g.627760G>A, MAP3K7CL:c.383_392ACTCCACAAA>GACT and DLA-DRB1*002:01

Transmission : Multifactorial

Patent : -

Notes : In some affected puppies, lesions may diminish with age and may or may not return at an older age. DMS is determined by a combination of genetic and environmental factors (vaccination, viral infection, stress, UV exposure, owner surrender, mistreatment)

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45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten