Shar Pei

Shar Pei

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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COUL-1 - Coat Colour

Presence of brown coat

Shar Pei

COUL-1 - Coat Colour

Presence of brown coat

Description: DNA test can identifying dogs carrying the genotype "Brown" (B Locus)

Symptoms : _

Age of onset : _

Frequency : _

Gene involved : TYRP1

Tested mutation : S41C, Q331X and 345delP

Transmission : Autosomal Recessive

Patent : _

Notes : _

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DIL - Dilution

Lighter coat colour

Shar Pei

DIL - Dilution

Lighter coat colour

Description: DNA test can identifying dogs carrying the genotype "Dilute" (D Locus)

Symptoms : Dilution or lightening effect of the solid colours

Age of onset : From birth

Frequency : _

Gene involved : MLPH

Tested mutation : c.-22G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Renal Amyloidosis

Kidney failure

Shar Pei

Renal Amyloidosis

Kidney failure

Speciality Nephrology

Description : Amyloid deposits in kidney

Symptoms : Excessive water consumption, weight loss, fatigue. Progressive and ultimately fatal renal failure

Age of onset : The age of cases is 2–12 years with a median of 6 years

Examination : Definitive diagnosis can be made only by histological analysis on kidney biopsy or post-mortem sample of kidney.

Progress : Thanks to the important participation of breeders, veterinarians and dog owners, we have been able to collect 99 samples of Shar-Pei older than 18 months and histologically characterized for renal amyloidosis. Among them, 40 were diagnosed with amyloidosi

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL). In case of death, whatever the reason : • Sample and put promptly a half kidney (sagittal section) in formalin for histological analysis, and a piece of tissue in alcohol (e.g. tongue) for DNA extraction. ANTAGENE co

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Teams of Dr Kerstin Lindblad-Toh (Broad Institute, Massachussetts, USA and Uppsala University, Sweden), Dr J. Abadie (National Veterinary School of Nantes, France) and Dr L. Tintle (USA)

Contact : mageane@antagene.com

Comment : Your involvement in research is essential to our progress.