Poodle

Poodle

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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NEWS - Neonatal Encephalopathy with Seizures

Brain disease

Poodle

NEWS - Neonatal Encephalopathy with Seizures

Brain disease

Description: Abnormal development and structure of the cerebellum

Symptoms : Poor growth, muscle weakness, whole-body tremors, ataxia, tonic-clonic seizures, death usually occurs in first week of life

Age of onset : From birth

Frequency : Not available

Gene involved : ATF2

Tested mutation : c.152T>G

Transmission : Autosomal Recessive

Patent : -

Notes :

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DM - Degenerative Myelopathy

Progressive paralysis

Poodle

DM - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : _

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : _

Notes :

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VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Poodle

VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation

Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases

Age of onset : From birth

Frequency : Not available

Gene involved : VWF

Tested mutation : c.7142C>T

Transmission : Autosomal Recessive

Patent : _

Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs

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COUL-2 - Coat Colour

Presence of brown or yellow coat

Poodle

COUL-2 - Coat Colour

Presence of brown or yellow coat

Description: DNA test can identifying dogs carrying the genotype "Brown" (Locus B) and the genotype "Yellow" (E Locus)

Symptoms : _

Age of onset : _

Frequency : _

Gene involved : TYRP1 and MC1R

Tested mutation : TYRP1: S41C, Q331X and 345delP MC1R: R306X

Transmission : Autosomal

Patent : _

Notes : _

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IC - Improper Coat - Furnishings

Type of coat

Poodle

IC - Improper Coat - Furnishings

Type of coat

Description: DNA test can identifying dogs carrying the trait smooth coat without furnishings also called improper coat in some breeds

Symptoms : Short hair on the head and face, as well as on lower legs

Age of onset : From birth

Frequency : Not available

Gene involved : RSPO2

Tested mutation : 167pb insertion

Transmission : Autosomal Recessive

Patent : -

Notes :

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PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Poodle

PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Description: Progressive rod-cone degeneration

Symptoms : Declining vision (at night and then in daylight) and eventual blindness

Age of onset : Between 3 and 8 years old

Frequency : 40% carriers in European population

Gene involved : PRCD

Tested mutation : c.5G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Melanoma

Pigment cell cancer

Poodle

Melanoma

Pigment cell cancer

Speciality Oncology

Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites. In this breed, the most commonly encountered type is oral melanoma.

Symptoms : -

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling. This project has been studied within the framework of the LUPA European project. A first dog cohort allowed to underline few regions of the canine genome linked to the disease. These regions include several candidate genes currently i

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

MVD - Mitral Valve Disease

Heart valve defect

Poodle

MVD - Mitral Valve Disease

Heart valve defect

Speciality Cardiology

Description : Degradation of the mitral valve causing a leak during cardiac contraction and partial regurgitation of blood. Late-onset progressive disorder

Symptoms : Cardiac arrhythmia, cardiac murmur, exercise intolerance, cardiac insufficiency

Age of onset : The average age of onset is between 6 and 8 years, but in some cases, first symptoms appear at 3-4 years old

Examination : Auscultation

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Team of Pr Valérie Chetboul (ENVA-UCA, France)

Contact : mageane@antagene.com

Comment : Other name: degenerative mitral valve disease

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Melanoma

Pigment cell cancer

Poodle

Melanoma

Pigment cell cancer

Speciality Oncology

Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites. In this breed, the most commonly encountered type is oral melanoma.

Symptoms : -

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling. This project has been studied within the framework of the LUPA European project. A first dog cohort allowed to underline few regions of the canine genome linked to the disease. These regions include several candidate genes currently i

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

MVD - Mitral Valve Disease

Heart valve defect

Poodle

MVD - Mitral Valve Disease

Heart valve defect

Speciality Cardiology

Description : Degradation of the mitral valve causing a leak during cardiac contraction and partial regurgitation of blood. Late-onset progressive disorder

Symptoms : Cardiac arrhythmia, cardiac murmur, exercise intolerance, cardiac insufficiency

Age of onset : The average age of onset is between 6 and 8 years, but in some cases, first symptoms appear at 3-4 years old

Examination : Auscultation

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Team of Pr Valérie Chetboul (ENVA-UCA, France)

Contact : mageane@antagene.com

Comment : Other name: degenerative mitral valve disease