Old English Sheepdog

Old English Sheepdog

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Old English Sheepdog

MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs

Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death

Age of onset : From birth

Frequency : 3%

Gene involved : MDR1

Tested mutation : c.295_298del

Transmission : Autosomal Codominant

Patent : VHL Licence

Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.

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PCD - Primary Ciliary Dyskinesia

Respiratory disorder

Old English Sheepdog

PCD - Primary Ciliary Dyskinesia

Respiratory disorder

Description: Defects in ciliated cells, particularly in the respiratory cilia

Symptoms : Recurrent infection of the upper and lower respiratory tract (sneezing, nasal discharge, cough and chronic bronchitis), hydrocephalus, reduced fertility in males

Age of onset : from a few weeks to months old

Frequency : 21% carriers in European population

Gene involved : CCDC39

Tested mutation : C.286C>T

Transmission : Autosomal Recessive

Patent : _

Notes : _

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HA - Cerebellar Ataxia

Nervous system degeneration

Old English Sheepdog

HA - Cerebellar Ataxia

Nervous system degeneration

Description: Cerebellum degeneration leading to slowly progressing loss of motor function

Symptoms : Progressive loss of coordination, truncal sway, intention tremor, severe gait disturbances

Age of onset : Between 6 months and 4 years old

Frequency : 11% carriers in American population

Gene involved : RAB24

Tested mutation : c.113A>C

Transmission : Autosomal Recessive

Patent : -

Notes :

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