Newfoundland

Newfoundland

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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CYST - Cystinuria

Kidney stones

Newfoundland

CYST - Cystinuria

Kidney stones

Description: Accumulation of cystine in kidney, which may further precipitate to form calculi (stones) and inflammation of the system

Symptoms : Difficulties to urinate, there may be blood in urine. Untreated, this disease can lead to kidney failure and death of the dog

Age of onset : From the age of 6 months

Frequency : Not available

Gene involved : SLC3A1

Tested mutation : c.586C>T

Transmission : Autosomal Recessive

Patent : _

Notes : _

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DM - Degenerative Myelopathy

Progressive paralysis

Newfoundland

DM - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : _

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : _

Notes :

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TP-A - Thrombopathia

Bleeding disorder

Newfoundland

TP-A - Thrombopathia

Bleeding disorder

Description: Abnormal platelet function preventing normal clotting

Symptoms : Recurrent nose bleeds, excessive bleeding of the gums, bruises, hematomas, internal bleeding, bloody or dark tarry feces, lameness

Age of onset : From birth

Frequency : Not available

Gene involved : RASGRP2

Tested mutation : c.982C>T

Transmission : Autosomal Recessive

Patent : -

Notes :

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COUL-1 - Coat Colour

Presence of brown coat

Newfoundland

COUL-1 - Coat Colour

Presence of brown coat

Description: DNA test can identifying dogs carrying the genotype "Brown" (B Locus)

Symptoms : _

Age of onset : _

Frequency : _

Gene involved : TYRP1

Tested mutation : S41C, Q331X and 345delP

Transmission : Autosomal Recessive

Patent : _

Notes : _

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Newfoundland

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Speciality Cardiology

Description : Myocardial degeneration resulting in a dilation of cardiac cavities and a thinning of the cardiac walls

Symptoms : Exercise intolerance, weight loss, cough, respiratory difficulties, abdominal distension, muscular weakness, loss of consciousness, syncope, sudden death

Age of onset : -

Examination : Echocardiography, Doppler, electrocardiography and/or radiography

Progress : Undergoing sampling. This project has been studied within the framework of the LUPA European project. A first dog cohort allowed to underline few regions of the canine genome linked to the disease. These regions include several candidate genes currently i

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : LUPA www.eurolupa.org, Uppsala University (Sweden)

Contact : mageane@antagene.com

Comment : -

Coxofemoral Dysplasia

Hip dysplasia

Newfoundland

Coxofemoral Dysplasia

Hip dysplasia

Speciality Orthopaedics

Description : Developmental disorder of hip resulting in a joint instability

Symptoms : Arthrosis, gait problems unrelated to the degree of dysplasia

Age of onset : -

Examination : Radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Newfoundland

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Speciality Cardiology

Description : Myocardial degeneration resulting in a dilation of cardiac cavities and a thinning of the cardiac walls

Symptoms : Exercise intolerance, weight loss, cough, respiratory difficulties, abdominal distension, muscular weakness, loss of consciousness, syncope, sudden death

Age of onset : -

Examination : Echocardiography, Doppler, electrocardiography and/or radiography

Progress : Undergoing sampling. This project has been studied within the framework of the LUPA European project. A first dog cohort allowed to underline few regions of the canine genome linked to the disease. These regions include several candidate genes currently i

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : LUPA www.eurolupa.org, Uppsala University (Sweden)

Contact : mageane@antagene.com

Comment : -

Coxofemoral Dysplasia

Hip dysplasia

Newfoundland

Coxofemoral Dysplasia

Hip dysplasia

Speciality Orthopaedics

Description : Developmental disorder of hip resulting in a joint instability

Symptoms : Arthrosis, gait problems unrelated to the degree of dysplasia

Age of onset : -

Examination : Radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -