Miniature Bull Terrier

Miniature Bull Terrier

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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PLL-A - Primary Lens Luxation

Lens displacement in the eye

Miniature Bull Terrier

PLL-A - Primary Lens Luxation

Lens displacement in the eye

Description: Partial or complete breakdown of the zonular ligaments suspending the lens

Symptoms : Reddened eye, pain, corneal oedema, glaucoma which can damage the optic nerve causing blindness

Age of onset : Between 3 and 8 years old

Frequency : 40%

Gene involved : ADAMTS17

Tested mutation : c.1473+1G>A

Transmission : Autosomal Recessive

Patent : _

Notes : Primary lens luxation affects both eyes although few weeks or few months can separate luxation from each eye. Some clinical cases are not associate with the mutation.

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

LAD - Lethal Acrodermatitis

Skin lesions and stunting

Miniature Bull Terrier

LAD - Lethal Acrodermatitis

Skin lesions and stunting

Speciality Dermatology

Description : Dermatosis occurring especially on extremities. The prognosis is very poor, dogs are often euthanized, if not died, before the age of one year.

Symptoms : Skin disease of the face and feet, stunting, splayed digits, eating difficulties, increased susceptibility to microbial infections due to skin lesions and severe immune deficiency. In some dogs over six months of age: inflammation around claws (paronychia), dermatological, respiratory and digestive inflammations, thickening (hyperkeratosis) of footpads, ocular and/or cardiac disorders

Age of onset : From birth

Examination : Histological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Teams of Drs C. André (CNRS of Rennes, France) and S. Küry (INSERM Nantes, France)

Contact : mageane@antagene.com

Comment : -

Spinning

Tail chasing

Miniature Bull Terrier

Spinning

Tail chasing

Speciality Neurology

Description : Disease classified as an obsessive compulsive disorder. Current hypothesis: syndrome suggested to resemble partial seizures (without loss of consciousness) during which an abnormal electrical activity occurs in the temporal lobe of the brain (brain area involved in behaviour).

Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail. Some cases may be associated with aggressiveness which is triggered without reason and/or growling against a person or an object, irrational fears or disorders of consciousness with an apparent disassociation of the environment (trance-like behaviour, hallucinatory fly-catching compulsions...).

Age of onset : Puppies can be affected as early as few months, but the hormonal changes at puberty appear to be involved in the onset or worsening of this disorder.

Examination : Neurological check-up

Progress : Undergoing sampling. The first genetic results would show a genetically complex disorder.

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist and team of Dr H. Lohi (University of Helsinki, Finland)

Contact : spinning@vetagro-sup.fr mageane@antagene.com

Comment : Your involvement in research is essential to our progress.

Deafness

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Miniature Bull Terrier

Deafness

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Speciality Neurology

Description : Unilateral or bilateral deafness. Deafness is easily diagnosed only when it is bilateral. In case of unilateral deafness, the anomaly is sometimes detected only by the BAER test.

Symptoms : -

Age of onset : From birth

Examination : Brainstem auditory-evoked response (BAER)

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : -

Contact : mageane@antagene.com

Comment : -