Miniature American Shepherd

Miniature American Shepherd

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Miniature American Shepherd

MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs

Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death

Age of onset : From birth

Frequency : Not available

Gene involved : MDR1

Tested mutation : c.295_298del

Transmission : Autosomal Codominant

Patent : VHL Licence

Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.

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HSF4-A - Hereditary Cataract

Lens opacity and blindness

Miniature American Shepherd

HSF4-A - Hereditary Cataract

Lens opacity and blindness

Description: Lens opacity which affect both eyes (not obligatory at the same time)

Symptoms : Observation of two different cataracts in this breed: - mild, early-onset, seldom leading to loss of vision - severe, may affect vision

Age of onset : -

Frequency : Not available

Gene involved : HSF4

Tested mutation : g.85286582delC

Transmission : Autosomal Codominant

Patent : -

Notes : Heterozygotes may have the mild form, homozygous mutated dogs mainly develop the severe form.

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CEA - Collie Eye Anomaly

Loss of vision

Miniature American Shepherd

CEA - Collie Eye Anomaly

Loss of vision

Description: Abnormal development of the choroid (a layer of tissue under the retina of the eye)

Symptoms : Variability of clinical signs according to the breed and individuals: - grade 1 and 2: mild form, without disablement and evolution - grade 3 and 4: severe form with retinal detachment and intraocular haemorrhage, might cause blindness

Age of onset : From the age of 8 weeks

Frequency : Not available

Gene involved : NHEJ1

Tested mutation : c.588+462_588+8260del7799bp

Transmission : Autosomal Recessive

Patent : _

Notes : Mild and severe forms being due to a single mutation in the same gene, dogs with a mild form may produce offspring presenting a severe form.

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PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Miniature American Shepherd

PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Description: Progressive rod-cone degeneration

Symptoms : Declining vision (at night and then in daylight) and eventual blindness

Age of onset : Between 2 and 12 years old

Frequency : Not available

Gene involved : PRCD

Tested mutation : c.5G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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CMR1 - Multifocal Retinopathy

Retinal detachments

Miniature American Shepherd

CMR1 - Multifocal Retinopathy

Retinal detachments

Description: Retinal pigment epithelial dysplasia causing localized multifocal retinal detachments

Symptoms : In the mild form, no vision disorders are reported despite the abnormal retina. In the severe form, lesions can lead to blindness

Age of onset : Before 4 months old

Frequency : Not available

Gene involved : BEST1

Tested mutation : c.73C>T

Transmission : Autosomal Recessive

Patent : _

Notes : _

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DM - Degenerative Myelopathy

Progressive paralysis

Miniature American Shepherd

DM - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : _

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : _

Notes :

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HUU - Hyperuricosuria

Predisposition to urate bladder stones

Miniature American Shepherd

HUU - Hyperuricosuria

Predisposition to urate bladder stones

Description: Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones

Symptoms : Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder

Age of onset : Between 3 and 6 years old

Frequency :

Gene involved : SLC2A9

Tested mutation : c.616G>T

Transmission : Autosomal Recessive

Patent : _

Notes : Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.

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QC - Short Tail

Presence of a naturally shortened tail

Miniature American Shepherd

QC - Short Tail

Presence of a naturally shortened tail

Description: DNA test can identifying dogs carrying the phenotype "Natural Bobtail"

Symptoms : Shortened tail, variability according to individuals: missing tail to 3/4 of tail length

Age of onset : _

Frequency : _

Gene involved : T

Tested mutation : c.295C>G

Transmission : Autosomal Dominant

Patent : _

Notes : _

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MERLE - Merle Coat Colour

M locus

Miniature American Shepherd

MERLE - Merle Coat Colour

M locus

Description: DNA test can identify dogs carrying the genotype "Merle" (M Locus) and highlight double merles and cryptic merles

Symptoms : Patches of diluted pigment intermingled with normal melanin, blue eyes, often associated with a wide range of auditory and ophthalmologic abnormalities. Double merles are predominantly white

Age of onset : From birth

Frequency : Not available

Gene involved : SILV

Tested mutation : SINE insertion

Transmission : Autosomal Dominant

Patent : -

Notes :

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Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat