Leonberger

Leonberger

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

Order

LPN1 - Juvenile-Onset Inherited Polyneuropathy

Neuromuscular Degeneration

Leonberger

LPN1 - Juvenile-Onset Inherited Polyneuropathy

Neuromuscular Degeneration

Description: Severe and progressive neuromuscular degeneration

Symptoms : Slowly worsening exercise intolerance, gait abnormalities, muscle atrophy of the pelvic limbs, noisy breathing, bark change, difficulty breathing

Age of onset : Before 4 years old

Frequency : 17% carriers

Gene involved : ARHGEF10

Tested mutation : c.1955_1958+6delCACGGTGAGC

Transmission : Autosomal Recessive

Patent : -

Notes : This mutation accounts about 20% of polyneuropathy cases in the Leonberger breed.

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Osteosarcoma

Bone tumour

Leonberger

Osteosarcoma

Bone tumour

Speciality Oncology

Description : This cancer essentially affects the long bones. It is locally aggressive and metastasizes rapidly.

Symptoms : Lameness

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France). http://dog-genetics.genouest.org/index.php?option=com_content&view=article&id=9&Itemid=17&lang=en

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Leonberger

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Speciality Cardiology

Description : Myocardial degeneration resulting in a dilation of cardiac cavities and a thinning of the cardiac walls

Symptoms : Exercise intolerance, weight loss, cough, respiratory difficulties, abdominal distension, muscular weakness, loss of consciousness, syncope, sudden death

Age of onset : -

Examination : Echocardiography, Doppler, electrocardiography and/or radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : -

Contact : mageane@antagene.com

Comment : -

Coxofemoral Dysplasia

Hip dysplasia

Leonberger

Coxofemoral Dysplasia

Hip dysplasia

Speciality Orthopaedics

Description : Developmental disorder of hip resulting in a joint instability

Symptoms : Arthrosis, gait problems unrelated to the degree of dysplasia

Age of onset : -

Examination : Radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Osteosarcoma

Bone tumour

Leonberger

Osteosarcoma

Bone tumour

Speciality Oncology

Description : This cancer essentially affects the long bones. It is locally aggressive and metastasizes rapidly.

Symptoms : Lameness

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France) http://dog-genetics.genouest.org/index.php?option=com_content&view=article&id=9&Itemid=17&lang=en

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Leonberger

DCM - Dilated Cardiomyopathy

Cardiac muscle degeneration

Speciality Cardiology

Description : Myocardial degeneration resulting in a dilation of cardiac cavities and a thinning of the cardiac walls

Symptoms : Exercise intolerance, weight loss, cough, respiratory difficulties, abdominal distension, muscular weakness, loss of consciousness, syncope, sudden death

Age of onset : -

Examination : Echocardiography, Doppler, electrocardiography and/or radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : -

Contact : mageane@antagene.com

Comment : -

Coxofemoral Dysplasia

Hip dysplasia

Leonberger

Coxofemoral Dysplasia

Hip dysplasia

Speciality Orthopaedics

Description : Developmental disorder of hip resulting in a joint instability

Symptoms : Arthrosis, gait problems unrelated to the degree of dysplasia

Age of onset : -

Examination : Radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -