Labrador Retriever

Labrador Retriever

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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CNM - Centronuclear Myopathy

Early muscular atrophy

Labrador Retriever

CNM - Centronuclear Myopathy

Early muscular atrophy

Description: Atrophy of muscle fibres due to myofibres remodelling

Symptoms : Muscle weakness, exercise intolerance. Onset of progressive weight loss by 15 days old

Age of onset : Between 2 and 5 months old

Frequency : Lower than 5% carriers

Gene involved : PTPLA

Tested mutation : c.191_192ins236b

Transmission : Autosomal Recessive

Patent : _

Notes : For more information: www.labradorcnm.com

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SD2 - Skeletal Dysplasia 2

Dwarfism

Labrador Retriever

SD2 - Skeletal Dysplasia 2

Dwarfism

Description: Abnormality of skeletal development leading to mild disproportionate dwarfism

Symptoms : Short legs with normal body length and width, lower shoulder height (< 50 cm) compared to the international breed standard (54-57 cm), not affecting health condition

Age of onset : -

Frequency : Not available

Gene involved : COL11A2

Tested mutation : c.143G>C

Transmission : Autosomal Recessive

Patent : -

Notes :

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PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Labrador Retriever

PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Description: Progressive rod-cone degeneration

Symptoms : Declining vision (at night and then in daylight) and eventual blindness

Age of onset : Between 1,5 and 6 years old

Frequency : 23% carriers in European population

Gene involved : PRCD

Tested mutation : c.5G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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COUL-2 - Coat Colour

Presence of brown or yellow coat

Labrador Retriever

COUL-2 - Coat Colour

Presence of brown or yellow coat

Description: DNA test can identifying dogs carrying the genotype "Brown" (Locus B) and the genotype "Yellow" (E Locus)

Symptoms : _

Age of onset : _

Frequency : _

Gene involved : TYRP1 and MC1R

Tested mutation : TYRP1: S41C, Q331X and 345delP MC1R: R306X

Transmission : Autosomal

Patent : _

Notes : _

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PL - Hair Length

Long coat / Short coat

Labrador Retriever

PL - Hair Length

Long coat / Short coat

Description: DNA test can identifying dogs carrying the genotype "Long Coat"

Symptoms : -

Age of onset : -

Frequency : -

Gene involved : FGF5

Tested mutation : c.284G>T

Transmission : Autosomal Recessive

Patent : -

Notes : -

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DIL - Dilution

Lighter coat colour

Labrador Retriever

DIL - Dilution

Lighter coat colour

Description: DNA test can identifying dogs carrying the genotype "Dilute" (D Locus)

Symptoms : Dilution or lightening effect of the solid colours

Age of onset : From birth

Frequency : _

Gene involved : MLPH

Tested mutation : c.-22G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Melanoma

Pigment cell cancer

Labrador Retriever

Melanoma

Pigment cell cancer

Speciality Oncology

Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites

Symptoms : -

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Melanoma

Pigment cell cancer

Labrador Retriever

Melanoma

Pigment cell cancer

Speciality Oncology

Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites

Symptoms : -

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -