Gordon Setter

Gordon Setter

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

DNA - based testing for hereditary diseases

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NCL-D - Neuronal Ceroid Lipofuscinosis

Nervous system degeneration (ataxia)

Gordon Setter

NCL-D - Neuronal Ceroid Lipofuscinosis

Nervous system degeneration (ataxia)

Description: Neurodegenerative disease leading to loss of motor function and vision and to behavioural disorder

Symptoms : Progressive loss of motor function and coordination (ataxia), behavioural disorder, blanks, progressive loss of vision

Age of onset : Between 12 and 18 months old

Frequency : 24% carriers in French population

Gene involved : CLN8

Tested mutation : c.491T>C

Transmission : Autosomal Recessive

Patent :

Notes : An another DNA test (HA) is available to detect an other form of ataxia in this breed.

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PRA-rcd4 -Progressive Retinal Atrophy

Progressive loss of vision

Gordon Setter

PRA-rcd4 -Progressive Retinal Atrophy

Progressive loss of vision

Description: Rod and cone dysplasia type 4

Symptoms : Progressive loss of vision (at night and then in daylight) culminating in blindness

Age of onset : Average age of 10 years, cases observed from 5 to 12 years old

Frequency : English population: 57% carriers ; American population: 34% carriers ; French population: 41% carriers

Gene involved : C2orf71

Tested mutation : c.3149_3150insC

Transmission : Autosomal Recessive

Patent :

Notes : This mutation accounts for 90% of PRA cases in the Gordon Setter breed.

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HA - Cerebellar Ataxia

Nervous system degeneration

Gordon Setter

HA - Cerebellar Ataxia

Nervous system degeneration

Description: Cerebellum degeneration leading to slowly progressing loss of motor function

Symptoms : Progressive loss of coordination, truncal sway, intention tremor, severe gait disturbances

Age of onset : Between 6 months and 4 years old

Frequency : Not available

Gene involved : RAB24

Tested mutation : c.113A>C

Transmission : Autosomal Recessive

Patent : -

Notes : An another DNA test (NCL-D) is available to detect an other form of ataxia in this breed.

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat