Golden Retriever

Golden Retriever

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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ICT-A - Ichthyosis

Overabundance of dandruffs

Golden Retriever

ICT-A - Ichthyosis

Overabundance of dandruffs

Description: The mutated gene is involved in the skin barrier lipid metabolism, its dysfunction leads to an abnormal desquamation

Symptoms : Large-sized dandruffs whitish then blackish, mainly on the trunk and particularly visible on the belly. In the worst forms, complications (bacterial, fungal or parasitic) are observed

Age of onset : Between 1 and 18 months old

Frequency : European population: 83% carriers ; American population: 61% carriers ; Australian population: 52% carriers

Gene involved : PNPLA1

Tested mutation : Indel in exon 8

Transmission : Autosomal Recessive

Patent : ANTAGENE Worldwide exclusive License

Notes : This DNA test is the result of researches and efforts to improve the health of purebreed dogs and cats. Only ANTAGENE masters the performing process of these DNA tests to garantee a 99.9% accuracy of the results delivered Legal mention : ICT-A test : CNRS-Rennes 1 patent ANTAGENE License

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GR-PRA1 - Progressive Retinal Atrophy

Progressive loss of vision

Golden Retriever

GR-PRA1 - Progressive Retinal Atrophy

Progressive loss of vision

Description: Progressive rod-cone degeneration

Symptoms : Progressive loss of vision (at night and then in daylight) culminating in blindness

Age of onset : Between 6 and 7 years old

Frequency : 4% carriers in French population - 8% carriers in English population

Gene involved : SLC4A3

Tested mutation : c.2601_2602insC

Transmission : Autosomal Recessive

Patent : -

Notes : Another DNA test (PRA-prcd) is available to detect another form of PRA in this breed.

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NCL-F - Neuronal Ceroid Lipofuscinosis

Nervous system degeneration

Golden Retriever

NCL-F - Neuronal Ceroid Lipofuscinosis

Nervous system degeneration

Description: Neurodegenerative disease leading to loss of motor function and vision and to behavioural disorder

Symptoms : Progressive loss of motor function and coordination (ataxia), visual impairment, behavioural disorder, anxiety, aggression, tremors, localized and generalized seizures

Age of onset : Between 12 and 18 months old

Frequency : Not available

Gene involved : CLN5

Tested mutation : c.934_935delAG

Transmission : Autosomal Recessive

Patent : -

Notes :

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DEB - Dystrophic Epidermolysis Bullosa

Cutaneous lesions

Golden Retriever

DEB - Dystrophic Epidermolysis Bullosa

Cutaneous lesions

Description: Abnormal collagen protein leading to separation of the epidermis from the underlying dermis

Symptoms : Blistering and ulcerations of the skin and inside the mouth and in the esophagus, growth retardation, nails dystrophy

Age of onset : From birth

Frequency : Lower than 1% carriers

Gene involved : COL7A1

Tested mutation : c.5716G>A

Transmission : Autosomal Recessive

Patent : -

Notes :

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PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Golden Retriever

PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Description: Progressive rod-cone degeneration

Symptoms : Declining vision (at night and then in daylight) and eventual blindness

Age of onset : Between 2 and 12 years old

Frequency : Not available

Gene involved : PRCD

Tested mutation : c.5G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

SH - Histiocytic sarcoma

Immune cancer

Golden Retriever

SH - Histiocytic sarcoma

Immune cancer

Speciality Oncology

Description : Tumour affecting histiocytes, cells responsible for immune function. Development of tumours spread throughout several organs (spleen, lungs, liver, lymph nodes…)

Symptoms : Weight loss, lethargy, anorexia, occasionally fever, cough and pale mucous membranes

Age of onset : The average age of detection is 6.5 years

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France). http://dog-genetics.genouest.org/index.php?option=com_content&view=article&id=9&Itemid=17&lang=en

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Melanoma

Pigment cell cancer

Golden Retriever

Melanoma

Pigment cell cancer

Speciality Oncology

Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites

Symptoms : -

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Ectopic Ureter

Malformation leading to urinary incontinence

Golden Retriever

Ectopic Ureter

Malformation leading to urinary incontinence

Speciality Urology

Description : Defect of embryonic development resulting in abnormally located terminal portion of the ureter

Symptoms : Urinary leakage, affects males and females but is more observable in females

Age of onset : From birth

Examination : Intravenous urography, echography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : -

Contact : mageane@antagene.com

Comment : -

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

SH - Histiocytic sarcoma

Immune cancer

Golden Retriever

SH - Histiocytic sarcoma

Immune cancer

Speciality Oncology

Description : Tumour affecting histiocytes, cells responsible for immune function. Development of tumours spread throughout several organs (spleen, lungs, liver, lymph nodes…)

Symptoms : Weight loss, lethargy, anorexia, occasionally fever, cough and pale mucous membranes

Age of onset : The average age of detection is 6.5 years

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France) http://dog-genetics.genouest.org/index.php?option=com_content&view=article&id=9&Itemid=17&lang=en

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Melanoma

Pigment cell cancer

Golden Retriever

Melanoma

Pigment cell cancer

Speciality Oncology

Description : Highly aggressive cancer occurring on the skin surface, in the eye and mucous membranous sites

Symptoms : -

Age of onset : -

Examination : Histological or cytological analyses

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Ectopic Ureter

Malformation leading to urinary incontinence

Golden Retriever

Ectopic Ureter

Malformation leading to urinary incontinence

Speciality Urology

Description : Defect of embryonic development resulting in abnormally located terminal portion of the ureter

Symptoms : Urinary leakage, affects males and females but is more observable in females

Age of onset : From birth

Examination : Intravenous urography, echography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : -

Contact : mageane@antagene.com

Comment : -