German Shepherd Dog

German Shepherd Dog

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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HUU - Hyperuricosuria

Predisposition to urate bladder stones

German Shepherd Dog

HUU - Hyperuricosuria

Predisposition to urate bladder stones

Description: Metabolic disorder resulting in elevated levels of uric acid in blood and urine. This trait predisposes dogs to form urate bladder stones

Symptoms : Difficulty urinating, blood in urine, urinary incontinence, abdominal pain. Some complications are possible: acute kidney failure, urinary tract infection, or rupture of bladder

Age of onset : Between 3 and 6 years old

Frequency :

Gene involved : SLC2A9

Tested mutation : c.616G>T

Transmission : Autosomal Recessive

Patent : _

Notes : Predisposition to urate bladder stones caused by this mutation is variable according to breeds. Most of homozygous mutated dogs never show symptoms.

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MDR1 - Multidrug Sensitivity

Poisoning after drug admission

German Shepherd Dog

MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs

Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death

Age of onset : From birth

Frequency : Not available

Gene involved : MDR1

Tested mutation : c.295_298del

Transmission : Autosomal Codominant

Patent : VHL Licence

Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.

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NAH - Pituitary Dwarfism

Growth retardation

German Shepherd Dog

NAH - Pituitary Dwarfism

Growth retardation

Description: Underdevelopment of the pituitary gland leading to pituitary hormone deficiency causing growth retardation

Symptoms : Marked growth retardation, small size, retention of puppy coat, lack of adult coat, bilateral symetrical loss of hair coat mostly located at the trunk, the neck and at the top of the legs Less frequent signs : hyperpigmentation of the skin, scales, bacterial infections

Age of onset : Significated clinical signs 2-3 months after birth

Frequency : 11% carriers in French population

Gene involved : LHX3

Tested mutation : 7bp del intron 5 affects splice site

Transmission : Autosomal Recessive

Patent : -

Notes : -

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DM - Degenerative Myelopathy

Progressive paralysis

German Shepherd Dog

DM - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : _

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : _

Notes :

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PL - Hair Length

Long coat / Short coat

German Shepherd Dog

PL - Hair Length

Long coat / Short coat

Description: DNA test can identifying dogs carrying the genotype "Long Coat"

Symptoms : _

Age of onset : _

Frequency : -

Gene involved : FGF5

Tested mutation : c.284G>T

Transmission : Autosomal Recessive

Patent : _

Notes : _

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DIL - Dilution

Lighter coat colour

German Shepherd Dog

DIL - Dilution

Lighter coat colour

Description: DNA test can identifying dogs carrying the genotype "Dilute" (D Locus)

Symptoms : Dilution or lightening effect of the solid colours

Age of onset : From birth

Frequency : _

Gene involved : MLPH

Tested mutation : c.-22G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Spinning

Tail chasing

German Shepherd Dog

Spinning

Tail chasing

Speciality Neurology

Description : Disease classified as an obsessive compulsive disorder

Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.

Age of onset : -

Examination : Neurological check-up

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist and team of Dr H. Lohi (University of Helsinki, Finland)

Contact : spinning@vetagro-sup.fr mageane@antagene.com

Comment : -

Coxofemoral Dysplasia

Hip dysplasia

German Shepherd Dog

Coxofemoral Dysplasia

Hip dysplasia

Speciality Orthopaedics

Description : Developmental disorder of hip resulting in a joint instability

Symptoms : Arthrosis, gait problems unrelated to the degree of dysplasia

Age of onset : -

Examination : Radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Spinning

Tail chasing

German Shepherd Dog

Spinning

Tail chasing

Speciality Neurology

Description : Disease classified as an obsessive compulsive disorder

Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.

Age of onset : -

Examination : Neurological check-up

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist and team of Dr H. Lohi (University of Helsinki, Finland)

Contact : spinning@vetagro-sup.fr mageane@antagene.com

Comment : -

Coxofemoral Dysplasia

Hip dysplasia

German Shepherd Dog

Coxofemoral Dysplasia

Hip dysplasia

Speciality Orthopaedics

Description : Developmental disorder of hip resulting in a joint instability

Symptoms : Arthrosis, gait problems unrelated to the degree of dysplasia

Age of onset : -

Examination : Radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -