English Cocker Spaniel

PRA-prcd - Progressive Retinal Atrophy

Progressive loss of vision

Description: Progressive rod-cone degeneration

Symptoms : Declining vision (at night and then in daylight) and eventual blindness

Age of onset : Between 2 and 8 years old

Frequency : 46% carriers in European population

Gene involved : PRCD

Tested mutation : c.5G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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English Cocker Spaniel

FN - Familial Nephropathy

Juvenile-onset renal failure

Description: Abnormal kidney basement membrane protein and structure

Symptoms : Excessive water consumption, excessive urine volume, weight loss, vomiting, diarrhoea, progressive and ultimately fatal renal failure

Age of onset : From birth, death before 2 years old

Frequency : 6% carriers in European population

Gene involved : COL4A4

Tested mutation : c.115A>T

Transmission : Autosomal Recessive

Patent : ANTAGENE European exclusive License

Notes : This DNA test is the result of researches and efforts to improve the health of purebreed dogs and cats. Only ANTAGENE masters the performing process of these DNA tests to garantee a 99.9% accuracy of the results delivered Legal mention : FN test : Merlogen patent ANTAGENE license

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English Cocker Spaniel

AMS - Acral Mutilation Syndrome

Lesions on distal extremities caused by self-mutilation

Description: Self-mutilation of limb extremities linked with located insensivity to pain

Symptoms : Lesions on distal extremities caused by self-mutilation, loss of sensivity to pain on distal limbs, tendency to lick or bite their own pads resulting in auto-amputation of claws, digits and footpads in severe cases, no limping

Age of onset : From 3 to 12 months

Frequency : 7% carriers in English population

Gene involved : -

Tested mutation : -

Transmission : Autosomal Recessive

Patent : -

Notes : This DNA test is the result of researches and efforts to improve the health and to determine the risk for purebreed dogs to develop Acral Mutilation Syndrome. The team "Canine Genetics" from CNRS-Université de Rennes I led the research that allowed the development of this risk test. Only Antagene masters the performing process of this DNA test.

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