Coton de Tulear

Coton de Tulear

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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BNAT - Neonatal Ataxia

Inability to move

Coton de Tulear

BNAT - Neonatal Ataxia

Inability to move

Description: Nervous system degeneration

Symptoms : Disorders of the balance with an incapacity to coordinate movements, inability to walk or to remain standing

Age of onset : From birth

Frequency : European population: 9% carriers ; American population: 13% carriers

Gene involved : GRM1

Tested mutation : retrotransposon insertion

Transmission : Autosomal Recessive

Patent : _

Notes : _

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CMR2 - Multifocal Retinopathy

Retinal detachments

Coton de Tulear

CMR2 - Multifocal Retinopathy

Retinal detachments

Description: Retinal pigment epithelial dysplasia causing localized multifocal retinal detachments

Symptoms : In the mild form, no vision disorders are reported despite the abnormal retina. In the severe form, lesions can lead to blindness

Age of onset : Before 4 months old

Frequency : 27%

Gene involved : BEST1

Tested mutation : c.482G>A

Transmission : Autosomal Recessive

Patent : _

Notes : _

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VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Coton de Tulear

VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation

Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases

Age of onset : From birth

Frequency : Not available

Gene involved : VWF

Tested mutation : c.7142C>T

Transmission : Autosomal Recessive

Patent : _

Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs

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DM - Degenerative Myelopathy

Progressive paralysis

Coton de Tulear

DM - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : _

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : _

Notes :

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Hereditary Cataract

Lens opacity and blindness

Coton de Tulear

Hereditary Cataract

Lens opacity and blindness

Speciality Ophthalmology

Description : Anterior and/or posterior subcapsular cataract

Symptoms : Partial or complete bilateral lens opacity causing visual impairment

Age of onset : Between 3 and 5 years old

Examination : Ophthalmic check-up

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : -

Contact : mageane@antagene.com

Comment : -

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Hereditary Cataract

Lens opacity and blindness

Coton de Tulear

Hereditary Cataract

Lens opacity and blindness

Speciality Ophthalmology

Description : Anterior and/or posterior subcapsular cataract

Symptoms : Partial or complete bilateral lens opacity causing visual impairment

Age of onset : Between 3 and 5 years old

Examination : Ophthalmic check-up

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : -

Contact : mageane@antagene.com

Comment : -