Cavalier King Charles Spaniel

Cavalier King Charles Spaniel

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

DNA - based testing for hereditary diseases

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EFS - Episodic Falling Syndrome

Collapse with increased limb extensor tone

Cavalier King Charles Spaniel

EFS - Episodic Falling Syndrome

Collapse with increased limb extensor tone

Description: Neurological condition leading to dyskinesia induced by exercise, excitement or stress and characterised by hypertonicity of all four limbs.

Symptoms : Muscular hypertonicity of the limbs and trunk muscles, "deer-stalker" gait leading sometimes to collapse

Age of onset : From 14 weeks to 4 years

Frequency : French population: 14,8% carriers ; English population: 8% carriers ; American population: 12,9% carriers

Gene involved : BCAN

Tested mutation : 15.7kb del, exons 1-3

Transmission : Autosomal Recessive

Patent :

Notes : Also called "sudden collapse". As Episodic Falling Syndrome is a highly variable condition, some homozygous mutated dogs will not show clinical signs of EFS. Conversely, some dogs can show symptoms close to EFS, this genetic test may then contribute to a differential diagnosis especially between this disease and different types of epilepsy.

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CKCSID - Congenital Keratoconjunctivitis Sicca and Ichtyosiform Dermatosis

Dry eye curly coat syndrome

Cavalier King Charles Spaniel

CKCSID - Congenital Keratoconjunctivitis Sicca and Ichtyosiform Dermatosis

Dry eye curly coat syndrome

Description: Conjunctivitis sicca associated with a frizzy characteristic coat present from birth

Symptoms : Ocular discharge due to reduced production of aqueous tears, persistent scale along the dorsal spine, frizzy and alopecic coat, gingivitis, hyperkeratinised abdominal skin and footpads with nail growth abnormalities

Age of onset : From birth

Frequency : French population : 7,3% carriers ; English population : 8% carriers

Gene involved : FAM83H

Tested mutation : c.1016delC (Exon 5)

Transmission : Autosomal Recessive

Patent : _

Notes : _

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

MVD - Mitral Valve Disease

Heart valve defect

Cavalier King Charles Spaniel

MVD - Mitral Valve Disease

Heart valve defect

Speciality Cardiology

Description : Degradation of the mitral valve causing a leak during cardiac contraction and partial regurgitation of blood. Late-onset progressive disorder

Symptoms : Cardiac arrhythmia, cardiac murmur, exercise intolerance, cardiac insufficiency

Age of onset : The average age of onset is between 6 and 8 years, but in some cases, first symptoms appear at 3-4 years old

Examination : Auscultation

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Team of Pr Valérie Chetboul (ENVA-UCA, France)

Contact : mageane@antagene.com

Comment : Other name: degenerative mitral valve disease

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

MVD - Mitral Valve Disease

Heart valve defect

Cavalier King Charles Spaniel

MVD - Mitral Valve Disease

Heart valve defect

Speciality Cardiology

Description : Degradation of the mitral valve causing a leak during cardiac contraction and partial regurgitation of blood. Late-onset progressive disorder

Symptoms : Cardiac arrhythmia, cardiac murmur, exercise intolerance, cardiac insufficiency

Age of onset : The average age of onset is between 6 and 8 years, but in some cases, first symptoms appear at 3-4 years old

Examination : Auscultation

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Team of Pr Valérie Chetboul (ENVA-UCA, France)

Contact : mageane@antagene.com

Comment : Other name: degenerative mitral valve disease