Border Collie

Border Collie

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

Order

CEA - Collie Eye Anomaly

Loss of vision

Border Collie

CEA - Collie Eye Anomaly

Loss of vision

Description: Abnormal development of the choroid (a layer of tissue under the retina of the eye)

Symptoms : Variability of clinical signs according to the breed and individuals: - grade 1 and 2: mild form, without disablement and evolution - grade 3 and 4: severe form with retinal detachment and intraocular haemorrhage, might cause blindness

Age of onset : From the age of 8 weeks

Frequency : Not available

Gene involved : NHEJ1

Tested mutation : c.588+462_588+8260del7799bp

Transmission : Autosomal Recessive

Patent : _

Notes : Mild and severe forms being due to a single mutation in the same gene, dogs with a mild form may produce offspring presenting a severe form.

PrintSend to a friendPartager sur Facebook

Order

IGS-A - Cobalamin Malabsorption

Imerslund-Gräsbeck syndrome

Border Collie

IGS-A - Cobalamin Malabsorption

Imerslund-Gräsbeck syndrome

Description: Selective intestinal cobalamin (vitamin B12) malabsorption

Symptoms : Growth retardation, lethargy, anorexia

Age of onset : Between 6 and 12 weeks old

Frequency : 9,5% carriers in European population

Gene involved : CUBN

Tested mutation : c.8392delC

Transmission : Autosomal Recessive

Patent : -

Notes :

PrintSend to a friendPartager sur Facebook

Order

MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Border Collie

MDR1 - Multidrug Sensitivity

Poisoning after drug admission

Description: Abnormal function of a blood-brain barrier protein resulting in neurotoxicity due to admission of some drugs

Symptoms : hypersalivation, vomiting, ataxia, blindness, tremor, depression, coma, possibly death

Age of onset : From birth

Frequency : Not available

Gene involved : MDR1

Tested mutation : c.295_298del

Transmission : Autosomal Codominant

Patent : VHL Licence

Notes : For more information about concerned drugs: www.vetmed.wsu.edu/depts-VCPL/drugs.aspx Heterozygotes may be subject to poisoning, with high variability between breeds, individuals, molecules and intake.

PrintSend to a friendPartager sur Facebook

Order

MERLE - Merle Coat Colour

M locus

Border Collie

MERLE - Merle Coat Colour

M locus

Description: DNA test can identify dogs carrying the genotype "Merle" (M Locus) and highlight double merles and cryptic merles

Symptoms : Patches of diluted pigment intermingled with normal melanin, blue eyes, often associated with a wide range of auditory and ophthalmologic abnormalities. Double merles are predominantly white

Age of onset : From birth

Frequency : Not available

Gene involved : SILV

Tested mutation : SINE insertion

Transmission : Autosomal Dominant

Patent : -

Notes :

PrintSend to a friendPartager sur Facebook

55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Spinning

Tail chasing

Border Collie

Spinning

Tail chasing

Speciality Neurology

Description : Disease classified as an obsessive compulsive disorder

Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.

Age of onset : -

Examination : Neurological check-up

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist

Contact : spinning@vetagro-sup.fr mageane@antagene.com

Comment : -

PRA - Progressive Retinal Atrophy

Progressive loss of vision

Border Collie

PRA - Progressive Retinal Atrophy

Progressive loss of vision

Speciality Ophthalmology

Description : Rod and cone dystrophy

Symptoms : loss of night vision and a progressive loss of day vision, resulting in complete blindness

Age of onset : The average age of onset is 3.5 years

Examination : Ophthalmoscopy, biomicroscopy, ERG

Progress : The CNRS of Rennes (France), in collaboration with AFBC (French Association of Border Collie) and thanks to Dr. G. Chaudieu who examined more than 400 Border collies, built a pedigree of nearly 200 dogs. Study of genetic transmission suggests a X-linked r

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Team of Dr C. André (CNRS of Rennes, France) and Dr G. Chaudieu, veterinary ophthalmologist (France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : Samples of affected dogs and their healthy/affected related dogs are still needed.

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

Spinning

Tail chasing

Border Collie

Spinning

Tail chasing

Speciality Neurology

Description : Disease classified as an obsessive compulsive disorder

Symptoms : Affected dogs spin rapidly in tight circles, more or less frequently, with or without apparent interest in the tail.

Age of onset : -

Examination : Neurological check-up

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. Escriou (VetAgro Sup, France), veterinary neurologist

Contact : spinning@vetagro-sup.fr mageane@antagene.com

Comment : -

PRA - Progressive Retinal Atrophy

Progressive loss of vision

Border Collie

PRA - Progressive Retinal Atrophy

Progressive loss of vision

Speciality Ophthalmology

Description : Rod and cone dystrophy

Symptoms : loss of night vision and a progressive loss of day vision, resulting in complete blindness

Age of onset : The average age of onset is 3.5 years

Examination : Ophthalmoscopy, biomicroscopy, ERG

Progress : The CNRS of Rennes (France), in collaboration with AFBC (French Association of Border Collie) and thanks to Dr. G. Chaudieu who examined more than 400 Border collies, built a pedigree of nearly 200 dogs. Study of genetic transmission suggests a X-linked r

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Team of Dr C. André (CNRS of Rennes, France) and Dr G. Chaudieu, veterinary ophthalmologist (France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : Samples of affected dogs and their healthy/affected related dogs are still needed.