Bernese Mountain Dog

Bernese Mountain Dog

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Bernese Mountain Dog

VWD1 - von Willebrand's Disease Type I

Mild bleeding disorder

Description: Insufficient synthesis of von Willebrand factor, a protein involved in blood coagulation

Symptoms : Important bleedings or haemorrhagic episodes, potentially lethal only after a surgical act or trauma. Spontaneous bleedings of mucous membranes observed in very rare cases

Age of onset : From birth

Frequency : Not available

Gene involved : VWF

Tested mutation : c.7142C>T

Transmission : Autosomal Recessive

Patent : _

Notes : Attenuate symptoms can exceptionally be observed in heterozygous dogs

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DM-SOD1A - Degenerative Myelopathy

Progressive paralysis

Bernese Mountain Dog

DM-SOD1A - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : American population: 61% carriers European population: 41% carriers

Gene involved : SOD1

Tested mutation : c.118G>A

Transmission : Autosomal Recessive

Patent : -

Notes : An another DNA test (DM-SOD1B) is available to detect an other form of degenerative myelopathy in this breed. Note : dogs heterozygous for both SOD1A and SOD1B can also develop degenerative myelopathy associated to this double heterozygosity.

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DM-SOD1B - Degenerative Myelopathy

Progressive paralysis

Bernese Mountain Dog

DM-SOD1B - Degenerative Myelopathy

Progressive paralysis

Description: Degenerative disease of the spinal cord causing progressive paralysis

Symptoms : Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.

Age of onset : Between 8 and 14 years old

Frequency : American population: 7% carriers French population: 12% carriers

Gene involved : SOD1

Tested mutation : c.52A>T

Transmission : Autosomal Recessive

Patent : -

Notes : An another DNA test (DM-SOD1A) is available to detect an other form of degenerative myelopathy in this breed. Note : dogs heterozygous for both SOD1A and SOD1B can also develop degenerative myelopathy associated to this double heterozygosity.

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55€ Order

Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

SH - Histiocytic sarcoma

Immune cancer

Bernese Mountain Dog

SH - Histiocytic sarcoma

Immune cancer

Speciality Oncology

Description : Tumour affecting histiocytes, cells responsible for immune function. Development of tumours spread throughout several organs (spleen, lungs, liver, lymph nodes…)

Symptoms : Weight loss, lethargy, anorexia, occasionally fever, cough and pale mucous membranes

Age of onset : The average age of detection is 6.5 years

Examination : Histological or cytological analyses

Progress : For over 8 years, the CNRS at Rennes has been conducting a genetic study. This research has allowed us to collect numerous samples (more than 1000 Bernese Mountain Dogs) of affected dogs as well as elderly healthy dogs. Thanks to the analysis of a large g

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France). http://dog-genetics.genouest.org/index.php?option=com_content&view=article&id=9&Itemid=17&lang=en

Contact : cani-dna@univ-rennes1.frmageane@antagene.com

Comment : You find how to order the test for Histiocytic Sarcoma (a genetic tool to aid breeders in selection) by clicking on the "order" tab at the top of the Homepage.

Coxofemoral Dysplasia

Hip dysplasia

Bernese Mountain Dog

Coxofemoral Dysplasia

Hip dysplasia

Speciality Orthopaedics

Description : Developmental disorder of hip resulting in a joint instability

Symptoms : Arthrosis, gait problems unrelated to the degree of dysplasia

Age of onset : -

Examination : Radiography

Progress : Undergoing sampling

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (2-4 mL)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : Dr C. André (CNRS of Rennes, France)

Contact : cani-dna@univ-rennes1.fr mageane@antagene.com

Comment : -