Maine Coon

Maine Coon

75€ (Except SH and OPTIGEN tests)

Antagene Séléction

DNA - based testing for hereditary diseases

ANTAGENE provides a certificate displaying the genetic status of a dog or a cat

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HCM-A - Hypertrophic cardiomyopathy

Cardiac insufficiency

Maine Coon

HCM-A - Hypertrophic cardiomyopathy

Cardiac insufficiency

Description: Progressive thickening of the cardiac muscle, notably a left ventricular hypertrophy, thereby obstructing the outflow of blood. The mutated protein is involved in the cardiac contraction.

Symptoms : Cardiac murmur, cardiac arrhythmia, breathing difficulty, exercise intolerance, fatigability

Age of onset : Between 4 months and 15 years old

Frequency : 27%

Gene involved : MYBPC

Tested mutation : c.91G>C (A31P)

Transmission : Autosomal Dominant

Patent : _

Notes : A great expression variability is observed: the severe form can cause sudden death before one year old and the mild form might be expressed from 10 years old. The DNA test cannot predict the age of onset nor the grade of the disease.

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PKD - Polycystic Kidney Disease

Kidney failure

Maine Coon

PKD - Polycystic Kidney Disease

Kidney failure

Description: Cysts compressing the renal tissue and preventing a correct kidney functioning

Symptoms : Excessive water consumption, excessive urine volume, weight loss, vomiting, lethargy, chronic and ultimately fatal renal failure

Age of onset : Between 2 and 10 years old

Frequency : Lower than 1% carriers

Gene involved : PKD1

Tested mutation : C.10063C>A

Transmission : Autosomal Dominant

Patent : _

Notes : The study of PKD mutation frequency shows a significant decrease since 2006 in the tested population.

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SMA - Spinal Muscular Atrophy

Muscle weakness

Maine Coon

SMA - Spinal Muscular Atrophy

Muscle weakness

Description: Degeneration of the spinal cord neurons activating skeletal muscles of the trunk and limbs

Symptoms : Muscle weakness, difficulty walking and jumping

Age of onset : From the age of 3 months

Frequency : 1%

Gene involved : LIX1

Tested mutation : 140kb del, exons 4-6

Transmission : Autosomal Recessive

Patent : _

Notes : _

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PKDef - Pyruvate Kinase Deficiency

Hemolytic anaemia

Maine Coon

PKDef - Pyruvate Kinase Deficiency

Hemolytic anaemia

Description: Lack of the pyruvate kinase enzyme causing an early destruction of red blood cells, leading to an anaemia more or less severe according to individuals

Symptoms : Lethargy, diarrhea, pale mucous membranes, lack of appetite, weight loss, icterus

Age of onset : Variable. Some rare cases declare an early severe form. Anaemia may only be moderate and intermittently detectable. In mild cases, symptoms may be late onset.

Frequency : 12% carriers in the studied population (USA and UK)

Gene involved : PKLR

Tested mutation : c.693+304G>A

Transmission : Autosomal Recessive

Patent :

Notes :

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Antagene Parenté

DNA - Certified parentage

ANTAGENE performs genetic identification and parentage verification for a puppy and a kitten

45€ Order

Antagene Identité

Genetic Identification

ANTAGENE produces an unique genetic fingerprint of a dog or a cat

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

PD - Polydactyly

Occurrence of supernumerary digits

Maine Coon

PD - Polydactyly

Occurrence of supernumerary digits

Speciality Aesthetic Trait

Description : Domestic cats usually have 18 digits: 5 digits on each front-paw and 4 digits on each rear-paw, while polydactyl cats may have additional digits on 1, 2, 3 or the four paws.

Symptoms : Polydactyly observed in Maine Coon cats is a non-syndromic pre-axial polydactyly. Two morphological types of these pre-axial polydactyly have been described in cats: “mitten-paw” and “hamburger-paw”, a phenotypic feature that results from variable length and morphology of the extra-digit(s).

Age of onset : From birth

Examination : Clinical examination, X-ray imaging of the four limbs

Progress : Thanks to breeders and owners, we have collected pedigree data and DNA from polydactyl and control Maine Coon cats living in France and the US. We found that only some of these cats carried one of the known mutations. Then, another autosomal dominant muta

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (1-3 mL) or, failing that, a cheek swab (with 2 cytobrushes)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : National Veterinary School of Alfort, France (Dr Abitbol)

Contact : m.abitbol@vet-alfort.fr mageane@antagene.com

Comment : Polydactyl cats from other breeds and outbred polydactyl cats may also be included in the study.

Programme de recherche

Research program

ANTAGENE is involved into discovering the causes of hereditary diseases and developp new DNA screening tests

PD - Polydactyly

Occurrence of supernumerary digits

Maine Coon

PD - Polydactyly

Occurrence of supernumerary digits

Speciality Aesthetic Trait

Description : Domestic cats usually have 18 digits: 5 digits on each front-paw and 4 digits on each rear-paw, while polydactyl cats may have additional digits on 1, 2, 3 or the four paws.

Symptoms : Polydactyly observed in Maine Coon cats is a non-syndromic pre-axial polydactyly. Two morphological types of these pre-axial polydactyly have been described in cats: “mitten-paw” and “hamburger-paw”, a phenotypic feature that results from variable length and morphology of the extra-digit(s).

Age of onset : From birth

Examination : Clinical examination, X-ray imaging of the four limbs

Progress : Thanks to breeders and owners, we have collected pedigree data and DNA from polydactyl and control Maine Coon cats living in France and the US. We found that only some of these cats carried one of the known mutations. Then, another autosomal dominant muta

Prélèvements pour participer à la recherche : Blood sample in EDTA tube (1-3 mL) or, failing that, a cheek swab (with 2 cytobrushes)

Documents to be attached to samples : Clinical certificate, Sampling certificate, Copy of pedigree

Collaboration : National Veterinary School of Alfort, France (Dr Abitbol)

Contact : m.abitbol@vet-alfort.fr mageane@antagene.com

Comment : Polydactyl cats from other breeds and outbred polydactyl cats may also be included in the study.