AMPN - Polyneuropathy/Alaskan Malamute

Race liée: 

Neuromuscular degeneration

Description: 
Progressive neuronal degeneration of peripheral nerves
Symptomes: 
Slowly worsening exercise intolerance, gait abnormalities, muscle atrophy of the pelvic limbs, noisy breathing, bark change, difficulty swallowing
Age d'aparition: 
Between 3 and 19 months old
Fréquence: 
18% carriers
Gène impliqué: 
NDRG1
Mutation testée: 
c.293G>T
Transmission: 
Autosomal Recessive
Brevet: 
-